Tdo2 tryptophan 2,3-dioxygenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tdo2provided by RGD
Official Full Name: tryptophan 2,3-dioxygenaseprovided by RGD
Primary source: RGD:68370
See related: Ensembl:ENSRNOG00000011612 AllianceGenome:RGD:68370
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TO; Tdo
Summary: Enables several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Involved in several processes, including L-tryptophan catabolic process to acetyl-CoA; response to cortisol; and response to nitroglycerin. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward (RPKM 3150.8) See more
Orthologs: all
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Genomic context

Location:: 2q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (169567656..169585586, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (167269581..167287511, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (180897059..180914919, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that stress-induced corticosterone and consequent activation of hepatic TDO, tryptophan metabolism and production of kynurenine provoke a depression-related behavioural phenotype
Title: Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour.
tryptophan oxygenase gene might rely on the binding of the enhancer (the -8.5kb S/MAR-GRE) and the promoter to the inner nuclear matrix.
Title: Interactions between the nuclear matrix and an enhancer of the tryptophan oxygenase gene.
Data support the involvement of insulin in modulation of glucocorticoid receptor signaling pathway which mediates, in part, the activity of tryptophan oxygenase.
Title: Comparative analysis of tryptophan oxygenase activity and glucocorticoid receptor under the influence of insulin.
these data show that the nucleosome array in the regulatory region of the actively transcribed tdo gene in vivo is disturbed.
Title: [Nucleosome remodeling on the regulatory region of the rat tryptophan dioxygenase (tdo) gene during transcription in vivo].
The cerebrocortical TDO2 genes were increased in aged rats. Certain age dependent transcriptional changes might influence the mechanism of Alzheimer dis and other neurodegenerative disorders.
Title: [The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain].

Submit: New GeneRIF Correction

General gene information

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Markers

RH142300 (e-PCR)
- UniSTS:231547

D2Rat352 (e-PCR), detects polymorphism
- UniSTS:227486

RH127308 (e-PCR)
- UniSTS:210618

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-tryptophan 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-tryptophan 2,3-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-tryptophan 2,3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables L-tryptophan 2,3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-tryptophan catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-tryptophan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-tryptophan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-tryptophan catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cortisol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dexamethasone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nitroglycerin	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tryptophan 2,3-dioxygenase

Names: TRPO; tryptamin 2,3-dioxygenase; tryptophan 2,3-dioxygenase A; tryptophan oxygenase; tryptophan pyrrolase; tryptophan-23-dioxygenase; tryptophanase

NP_071798.1

EC 1.13.11.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.