Format

Send to:

Choose Destination

Pmpcb peptidase, mitochondrial processing subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 64198, updated on 12-Jan-2022

Summary

Official Symbol
Pmpcbprovided by RGD
Official Full Name
peptidase, mitochondrial processing subunit betaprovided by RGD
Primary source
RGD:621297
See related
Ensembl:ENSRNOG00000012693
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mppb
Summary
Enables metalloendopeptidase activity. Contributes to metallopeptidase activity. Involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Part of mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 6. Orthologous to human PMPCB (peptidase, mitochondrial processing subunit beta). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Heart (RPKM 633.1), Adrenal (RPKM 516.2) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pmpcb in Genome Data Viewer
Location:
4q11
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13297583..13310363, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (9908838..9921615, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene hypothetical LOC362306 Neighboring gene N-acyl phosphatidylethanolamine phospholipase D

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of mitochondrial processing peptidase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitochondrial-processing peptidase subunit beta
Names
P-52
beta-MPP
mitochondrial processing peptidase beta subunit
peptidase (mitochondrial processing) beta
peptidase, mitochondrial processing beta subunit
NP_071790.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022395.2NP_071790.1  mitochondrial-processing peptidase subunit beta precursor

    See identical proteins and their annotated locations for NP_071790.1

    Status: PROVISIONAL

    Source sequence(s)
    L12965
    UniProtKB/Swiss-Prot
    Q03346
    Related
    ENSRNOP00000017017.4, ENSRNOT00000017018.6
    Conserved Domains (3) summary
    COG0612
    Location:46478
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    pfam00675
    Location:68215
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:220404
    Peptidase_M16_C; Peptidase M16 inactive domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    13297583..13310363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center