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Clec10a C-type lectin domain containing 10A [ Rattus norvegicus (Norway rat) ]

Gene ID: 64195, updated on 29-Feb-2024

Summary

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Official Symbol
Clec10aprovided by RGD
Official Full Name
C-type lectin domain containing 10Aprovided by RGD
Primary source
RGD:621158
See related
Ensembl:ENSRNOG00000018715 AllianceGenome:RGD:621158
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mgl; Mgl1; Mgll
Summary
Predicted to enable carbohydrate binding activity. Predicted to act upstream of or within connective tissue replacement involved in inflammatory response wound healing. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC10A (C-type lectin domain containing 10A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 149.3), Heart (RPKM 108.1) and 9 other tissues See more
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Genomic context

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Location:
10q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55374914..55379110)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54876244..54880439)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56764927..56769447)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit gamma like 5 Neighboring gene asialoglycoprotein receptor 2 Neighboring gene solute carrier family 16, member 13 Neighboring gene solute carrier family 16, member 11 Neighboring gene uncharacterized LOC120095129 Neighboring gene BCL6B, transcription repressor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural similarity between the macrophage lectin specific for galactose/N-acetylgalactosamine and the hepatic asialoglycoprotein binding protein. Ii M, et al. Biochem Biophys Res Commun, 1988 Sep 15. PMID 3421964
  2. Molecular cloning and sequence analysis of cDNA encoding the macrophage lectin specific for galactose and N-acetylgalactosamine. Ii M, et al. J Biol Chem, 1990 Jul 5. PMID 2358462
  3. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Gulyas AI, et al. Eur J Neurosci, 2004 Jul. PMID 15233753
  4. Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a. Sato K, et al. Blood, 2005 Jul 1. PMID 15784728
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MGL is presynaptic enzyme of hippocampus, cerebellum and amygdala.
    Title: Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables fucose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological process involved in interspecies interaction between organisms IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-type lectin domain family 10 member A
Names
C-type lectin domain family 10, member A
Gal/GalNAc-specific lectin
M-ASGP-BP
M-ASGP-BP-1
MMGL
macrophage asialoglycoprotein-binding protein 1
macrophage galactose N-acetyl-galactosamine specific lectin 1
macrophage galactose/N-acetylgalactosamine-specific lectin
monoglyceride lipase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022393.2 → NP_071788.2  C-type lectin domain family 10 member A

    See identical proteins and their annotated locations for NP_071788.2

    Status: PROVISIONAL

    Source sequence(s)
    BC091151
    UniProtKB/Swiss-Prot
    P49301
    UniProtKB/TrEMBL
    A6HG26, F7EKK3, Q5BKA0
    Related
    ENSRNOP00000025308.2, ENSRNOT00000025308.5
    Conserved Domains (3) summary
    cd03590
    Location:175 → 300
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam01442
    Location:62 → 165
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam03954
    Location:18 → 165
    Lectin_N; Hepatic lectin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55374914..55379110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767868.3 → XP_008766090.1  C-type lectin domain family 10 member A isoform X1

    See identical proteins and their annotated locations for XP_008766090.1

    UniProtKB/Swiss-Prot
    P49301
    Conserved Domains (3) summary
    cd03590
    Location:176 → 301
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam01442
    Location:63 → 166
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam03954
    Location:21 → 166
    Lectin_N; Hepatic lectin, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49301.1 GenPept UniProtKB/Swiss-Prot:P49301

Gene LinkOut

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