U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dhcr7 7-dehydrocholesterol reductase [ Rattus norvegicus (Norway rat) ]

Gene ID: 64191, updated on 16-Jun-2026
Official Symbol
Dhcr7provided by RGD
Official Full Name
7-dehydrocholesterol reductaseprovided by RGD
Primary source
RGD:621769
See related
Ensembl:ENSRNOG00000020776 AllianceGenome:RGD:621769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 7-dehydrocholesterol reductase activity. Involved in cholesterol biosynthetic process and regulation of cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum and nuclear outer membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Behcet's disease and Smith-Lemli-Opitz syndrome. Orthologous to human DHCR7 (7-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Adrenal (RPKM 460.5), Liver (RPKM 232.8) and 5 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Dhcr7 in Genome Data Viewer
Location:
1q42
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208444434..208460408)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (199015081..199031055)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (217018916..217034890)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member E Neighboring gene NAD synthetase 1 Neighboring gene actin-like Neighboring gene 60S ribosomal protein L21-like Neighboring gene SH3 and multiple ankyrin repeat domains 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Effect of DHCR7 for the co-occurrence of hypercholesterolemia and vitamin D deficiency in type 2 diabetes: Perspective of health prevention. Sun L, et al. Prev Med, 2023 Aug. PMID 37329988
  2. Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation. Shefer S, et al. J Lipid Res, 1998 Dec. PMID 9831636
  3. Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein. Bae SH, et al. J Biol Chem, 1999 May 21. PMID 10329655
  4. Evidence for requirement of NADPH-cytochrome P450 oxidoreductase in the microsomal NADPH-sterol Delta7-reductase system. Nishino H, et al. Arch Biochem Biophys, 2000 Feb 15. PMID 10666310
  5. Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene. Lee JN, et al. Biochim Biophys Acta, 2002 Jun 7. PMID 12031495

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effect of DHCR7 for the co-occurrence of hypercholesterolemia and vitamin D deficiency in type 2 diabetes: Perspective of health prevention.
    Title: Effect of DHCR7 for the co-occurrence of hypercholesterolemia and vitamin D deficiency in type 2 diabetes: Perspective of health prevention.
  2. gene structure and alternative splicing
    Title: Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC93039

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 7-dehydrocholesterol reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 7-dehydrocholesterol reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables 7-dehydrocholesterol reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 7-dehydrocholesterol reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables 7-dehydrocholesterol reductase activity TAS
Traceable Author Statement
more info
 PubMed 
enables NADP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cholesterol-5,6-oxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables cholesterol-5,6-oxide hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables cholesterol-5,6-oxide hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol biosynthetic process IC
Inferred by Curator
more info
 PubMed 
involved_in cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ferroptosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
7-dehydrocholesterol reductase
Names
7-DHC reductase
cholesterol-5,6-epoxide hydrolase subunit DHCR7
sterol Delta(7)-reductase
NP_071784.1
XP_006230955.1
XP_006230956.1
XP_038945428.1
XP_063128807.1
XP_063128808.1
XP_063128809.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001438360.1 → NP_001425289.1  7-dehydrocholesterol reductase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q9Z2Z8
    UniProtKB/TrEMBL
    A0ACJ1LJV2

  2. NM_001438361.1 → NP_001425290.1  7-dehydrocholesterol reductase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q9Z2Z8
    UniProtKB/TrEMBL
    A0ACJ1LJV2

  3. NM_001438362.1 → NP_001425291.1  7-dehydrocholesterol reductase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q9Z2Z8
    UniProtKB/TrEMBL
    A0ACJ1LJV2

  4. NM_001438363.1 → NP_001425292.1  7-dehydrocholesterol reductase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q9Z2Z8
    UniProtKB/TrEMBL
    A0ACJ1LJV2

  5. NM_022389.4 → NP_071784.1  7-dehydrocholesterol reductase

    See identical proteins and their annotated locations for NP_071784.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q9Z2Z8
    UniProtKB/TrEMBL
    A0ACJ1LJV2
    Related
    ENSRNOP00000028194.3, ENSRNOT00000028195.7
    Conserved Domains (1) summary
    cl21511
    Location:89 → 471
    PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    208444434..208460408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272737.1 → XP_063128807.1  

  2. XM_006230893.5 → XP_006230955.1  

    Related
    ENSRNOP00000071939.2, ENSRNOT00000078979.3
    Conserved Domains (1) summary
    cl21511
    Location:89 → 471
    PEMT; Phospholipid methyltransferase

  3. XM_039089500.2 → XP_038945428.1  

    Conserved Domains (1) summary
    cl21511
    Location:89 → 471
    PEMT; Phospholipid methyltransferase

  4. XM_006230894.5 → XP_006230956.1  

    Conserved Domains (1) summary
    cl21511
    Location:89 → 471
    PEMT; Phospholipid methyltransferase

  5. XM_063272739.1 → XP_063128809.1  7-dehydrocholesterol reductase isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2Z8
    UniProtKB/TrEMBL
    A0ACJ1LJV2

  6. XM_063272738.1 → XP_063128808.1  7-dehydrocholesterol reductase isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2Z8
    UniProtKB/TrEMBL
    A0ACJ1LJV2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2Z8.1 GenPept UniProtKB/Swiss-Prot:Q9Z2Z8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous