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EDDM3B epididymal protein 3B [ Homo sapiens (human) ]

Gene ID: 64184, updated on 5-Sep-2021

Summary

Official Symbol
EDDM3Bprovided by HGNC
Official Full Name
epididymal protein 3Bprovided by HGNC
Primary source
HGNC:HGNC:19223
See related
Ensembl:ENSG00000181552 MIM:611582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP3B; HE3B; RAM2; FAM12B; HE3-BETA
Summary
Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See EDDM3B in Genome Data Viewer
Location:
14q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20768404..20770948)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21236563..21239107)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RAN binding protein 20 pseudogene Neighboring gene uncharacterized LOC107984671 Neighboring gene epididymal protein 3A Neighboring gene epididymal protein 3D, pseudogene Neighboring gene ribonuclease A family member k6 Neighboring gene uncharacterized LOC105370397 Neighboring gene ribonuclease A family member 1, pancreatic

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
epididymal secretory protein E3-beta
Names
family with sequence similarity 12, member B (epididymal)
human epididymis-specific 3 beta
human epididymis-specific protein 3-beta
ribonuclease A M2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022360.5NP_071755.1  epididymal secretory protein E3-beta precursor

    See identical proteins and their annotated locations for NP_071755.1

    Status: VALIDATED

    Source sequence(s)
    AI075915, AL163636, AY358865, BX112699
    Consensus CDS
    CCDS9557.1
    UniProtKB/Swiss-Prot
    P56851
    UniProtKB/TrEMBL
    W0UV31
    Related
    ENSP00000314810.3, ENST00000326783.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20768404..20770948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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