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NECAB1 N-terminal EF-hand calcium binding protein 1 [ Homo sapiens (human) ]

Gene ID: 64168, updated on 18-Aug-2020

Summary

Official Symbol
NECAB1provided by HGNC
Official Full Name
N-terminal EF-hand calcium binding protein 1provided by HGNC
Primary source
HGNC:HGNC:20983
See related
Ensembl:ENSG00000123119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EFCBP1; STIP-1
Expression
Biased expression in brain (RPKM 31.1), testis (RPKM 8.9) and 12 other tissues See more
Orthologs

Genomic context

See NECAB1 in Genome Data Viewer
Location:
8q21.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (90791768..90959393)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (91803921..91971630)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724670 Neighboring gene uncharacterized LOC105375633 Neighboring gene uncharacterized LOC105375635 Neighboring gene uncharacterized LOC105375634 Neighboring gene chromosome 8 open reading frame 88 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 Neighboring gene OTUD6B antisense RNA 1 (head to head)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
blastocyst hatching IEA
Inferred from Electronic Annotation
more info
 
regulation of amyloid precursor protein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
N-terminal EF-hand calcium-binding protein 1
Names
EF-hand calcium-binding protein 1
neuronal calcium binding protein
neuronal calcium-binding protein 1
synaptotagmin interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022351.5NP_071746.1  N-terminal EF-hand calcium-binding protein 1

    See identical proteins and their annotated locations for NP_071746.1

    Status: VALIDATED

    Source sequence(s)
    AF414126
    Consensus CDS
    CCDS47889.1
    UniProtKB/Swiss-Prot
    Q8N987
    Related
    ENSP00000387380.2, ENST00000417640.7
    Conserved Domains (3) summary
    pfam03992
    Location:254325
    ABM; Antibiotic biosynthesis monooxygenase
    pfam13499
    Location:3389
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:3187
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    90791768..90959393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517213.2XP_011515515.1  N-terminal EF-hand calcium-binding protein 1 isoform X1

    Conserved Domains (3) summary
    pfam03992
    Location:254315
    ABM; Antibiotic biosynthesis monooxygenase
    pfam13499
    Location:3389
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:3187
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
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