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Dtnbp1 dystrobrevin binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 641528, updated on 30-Sep-2021

Summary

Official Symbol
Dtnbp1provided by RGD
Official Full Name
dystrobrevin binding protein 1provided by RGD
Primary source
RGD:1590759
See related
EnsemblRapid:ENSRNOG00000048719
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Kidney (RPKM 175.2), Muscle (RPKM 109.9) and 9 other tissues See more
Orthologs
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Genomic context

See Dtnbp1 in Genome Data Viewer
Location:
17p14
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (19685218..19776668)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (20090136..20182332)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene jumonji and AT-rich interaction domain containing 2 Neighboring gene uncharacterized LOC120097934 Neighboring gene uncharacterized LOC120097859

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in anterograde axonal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in anterograde axonal transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in anterograde synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in anterograde synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
 
involved_in anterograde synaptic vesicle transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in organelle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet dense granule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within platelet dense granule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dopamine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
part_of BLOC-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of BLOC-1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of BLOC-1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
dysbindin
Names
BLOC-1 subunit 8
biogenesis of lysosome-related organelles complex 1 subunit 8
distrobrevin binding protein 1
dysbindin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037664.1NP_001032753.1  dysbindin

    See identical proteins and their annotated locations for NP_001032753.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088267
    UniProtKB/Swiss-Prot
    Q5M834
    Related
    ENSRNOP00000091788.1, ENSRNOT00000102493.1
    Conserved Domains (1) summary
    pfam04440
    Location:175316
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    19685218..19776668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096045.1XP_038951973.1  dysbindin isoform X1

    Conserved Domains (1) summary
    pfam04440
    Location:94271
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
  2. XM_039096046.1XP_038951974.1  dysbindin isoform X2

    Conserved Domains (1) summary
    pfam04440
    Location:94234
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
  3. XM_039096048.1XP_038951976.1  dysbindin isoform X4

    Conserved Domains (1) summary
    pfam04440
    Location:17194
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
  4. XM_039096047.1XP_038951975.1  dysbindin isoform X3

    Conserved Domains (1) summary
    pfam04440
    Location:19196
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
  5. XM_039096049.1XP_038951977.1  dysbindin isoform X5

    Conserved Domains (1) summary
    pfam04440
    Location:19159
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
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