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DEFB109B defensin beta 109B [ Homo sapiens (human) ]

Gene ID: 641517, updated on 5-Aug-2022

Summary

Official Symbol
DEFB109Bprovided by HGNC
Official Full Name
defensin beta 109Bprovided by HGNC
Primary source
HGNC:HGNC:33469
See related
AllianceGenome:HGNC:33469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBD9; DEFB109; DEF109P1B; DEFB109P1B
Summary
Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis and defense response to bacterium. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See DEFB109B in Genome Data Viewer
Location:
8p23.1
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (7309535..7320096)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (7038512..7049075)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7167057..7177618)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901877 Neighboring gene putative protein FAM90A5 Neighboring gene putative protein FAM90A20 Neighboring gene family with sequence similarity 66 member B Neighboring gene ubiquitin specific peptidase 17 like family member 1 Neighboring gene ubiquitin specific peptidase 17 like family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CCR6 chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative beta-defensin 109B
Names
defensin beta 109 pseudogene 1B
defensin, beta 9 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037380.2NP_001032457.1  putative beta-defensin 109B precursor

    Status: VALIDATED

    Source sequence(s)
    AF228730
    UniProtKB/Swiss-Prot
    Q30KR1

RNA

  1. NR_172880.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF228730

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    7309535..7320096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187570.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    665..11247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    7038512..7049075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_055544.1: Suppressed sequence

    Description
    NG_055544.1: This RefSeq was removed because it is now thought that this locus encodes a protein.
  2. NR_003668.2: Suppressed sequence

    Description
    NR_003668.2: This RefSeq was removed because there is insufficient evidence that this locus is transcribed.