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SELENOW selenoprotein W [ Homo sapiens (human) ]

Gene ID: 6415, updated on 5-Apr-2020

Summary

Official Symbol
SELENOWprovided by HGNC
Official Full Name
selenoprotein Wprovided by HGNC
Primary source
HGNC:HGNC:10752
See related
Ensembl:ENSG00000178980 MIM:603235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
selW; SEPW1
Summary
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in heart (RPKM 246.5), brain (RPKM 150.5) and 23 other tissues See more
Orthologs

Genomic context

See SELENOW in Genome Data Viewer
Location:
19q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (47778703..47784682)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48281842..48287939)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NOP53 ribosome biogenesis factor Neighboring gene NOP53 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene ribosomal protein L23a pseudogene 80 Neighboring gene tetrapeptide repeat homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
response to selenium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
selenoprotein W
Names
selenoprotein W, 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003009.4NP_003000.1  selenoprotein W

    See identical proteins and their annotated locations for NP_003000.1

    Status: REVIEWED

    Source sequence(s)
    AC008745, BC039597, CR991097
    Consensus CDS
    CCDS59402.1
    UniProtKB/Swiss-Prot
    P63302
    Related
    ENSP00000473185.1, ENST00000601048.6
    Conserved Domains (1) summary
    TIGR02174
    Location:578
    CXXU_selWTH; selT/selW/selH selenoprotein domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    47778703..47784682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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