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KIF9 kinesin family member 9 [ Homo sapiens (human) ]

Gene ID: 64147, updated on 7-Jun-2020

Summary

Official Symbol
KIF9provided by HGNC
Official Full Name
kinesin family member 9provided by HGNC
Primary source
HGNC:HGNC:16666
See related
Ensembl:ENSG00000088727 MIM:607910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 11.7), thyroid (RPKM 1.7) and 10 other tissues See more
Orthologs

Genomic context

See KIF9 in Genome Data Viewer
Location:
3p21.31
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (47227998..47282847, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47269516..47324337, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene neurotrophin receptor associated death domain, pseudogene Neighboring gene mitochondrial ribosomal protein L57 pseudogene 3 Neighboring gene SET domain containing 2, histone lysine methyltransferase Neighboring gene KIF9 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 13J Neighboring gene kelch like family member 18 Neighboring gene protein tyrosine phosphatase non-receptor type 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104186

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organelle disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
podosome IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF9
Names
kinesin protein 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134878.2NP_001128350.1  kinesin-like protein KIF9 isoform 2

    See identical proteins and their annotated locations for NP_001128350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and includes an alternate in-frame exon in the mid coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1. Both variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AI741745, AK292547, AK314418
    Consensus CDS
    CCDS2752.1
    UniProtKB/Swiss-Prot
    Q9HAQ2
    UniProtKB/TrEMBL
    A8K932
    Related
    ENSP00000391100.2, ENST00000452770.6
    Conserved Domains (2) summary
    cd01375
    Location:6338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:12340
    Kinesin; Kinesin motor domain
  2. NM_001377474.1NP_001364403.1  kinesin-like protein KIF9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104447
  3. NM_001377475.1NP_001364404.1  kinesin-like protein KIF9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC104447
  4. NM_001377476.1NP_001364405.1  kinesin-like protein KIF9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC104447
    Related
    ENSP00000391099.1, ENST00000432493.5
  5. NM_001377477.1NP_001364406.1  kinesin-like protein KIF9 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC104447
    Related
    ENSP00000406815.1, ENST00000425853.5
  6. NM_022342.5NP_071737.1  kinesin-like protein KIF9 isoform 1

    See identical proteins and their annotated locations for NP_071737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AF311212, AI741745, AK292547
    Consensus CDS
    CCDS2751.1
    UniProtKB/Swiss-Prot
    Q9HAQ2
    UniProtKB/TrEMBL
    A8K932
    Related
    ENSP00000414987.2, ENST00000444589.6
    Conserved Domains (2) summary
    cd01375
    Location:6338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:12340
    Kinesin; Kinesin motor domain
  7. NM_182902.4NP_878905.2  kinesin-like protein KIF9 isoform 2

    See identical proteins and their annotated locations for NP_878905.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon in the mid coding region, compared to variant 1, and encodes an isoform (2) that is longer than isoform 1. Both variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC104447, AI741745, AK292547, AK314418, BC030657
    Consensus CDS
    CCDS2752.1
    UniProtKB/Swiss-Prot
    Q9HAQ2
    UniProtKB/TrEMBL
    A8K932
    Related
    ENSP00000333942.2, ENST00000335044.6
    Conserved Domains (2) summary
    cd01375
    Location:6338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:12340
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    47227998..47282847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534006.2XP_011532308.1  kinesin-like protein KIF9 isoform X7

    Conserved Domains (1) summary
    cl22853
    Location:30245
    Motor_domain; Myosin and Kinesin motor domain
  2. XM_017007030.1XP_016862519.1  kinesin-like protein KIF9 isoform X6

    Conserved Domains (2) summary
    cl22853
    Location:6263
    Motor_domain; Myosin and Kinesin motor domain
    pfam00225
    Location:12265
    Kinesin; Kinesin motor domain
  3. XM_011534004.2XP_011532306.1  kinesin-like protein KIF9 isoform X3

    See identical proteins and their annotated locations for XP_011532306.1

    UniProtKB/Swiss-Prot
    Q9HAQ2
    Conserved Domains (2) summary
    cd01375
    Location:6338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:12340
    Kinesin; Kinesin motor domain
  4. XM_006713291.3XP_006713354.1  kinesin-like protein KIF9 isoform X5

    Conserved Domains (2) summary
    cl22853
    Location:39296
    Motor_domain; Myosin and Kinesin motor domain
    pfam00225
    Location:45298
    Kinesin; Kinesin motor domain
  5. XM_005265389.4XP_005265446.1  kinesin-like protein KIF9 isoform X4

    Conserved Domains (2) summary
    cd01375
    Location:39371
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:45373
    Kinesin; Kinesin motor domain
  6. XM_005265388.4XP_005265445.1  kinesin-like protein KIF9 isoform X1

    Conserved Domains (2) summary
    cd01375
    Location:39371
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:45373
    Kinesin; Kinesin motor domain
  7. XM_017007029.1XP_016862518.1  kinesin-like protein KIF9 isoform X3

    UniProtKB/Swiss-Prot
    Q9HAQ2
    Conserved Domains (2) summary
    cd01375
    Location:6338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:12340
    Kinesin; Kinesin motor domain
  8. XM_011534003.2XP_011532305.1  kinesin-like protein KIF9 isoform X2

    Conserved Domains (2) summary
    cd01375
    Location:20352
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:26354
    Kinesin; Kinesin motor domain
  9. XM_011534007.2XP_011532309.1  kinesin-like protein KIF9 isoform X9

RNA

  1. XR_940489.2 RNA Sequence

  2. XR_002959567.1 RNA Sequence

  3. XR_940488.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182903.2: Suppressed sequence

    Description
    NM_182903.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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