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Mllt1 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 [ Mus musculus (house mouse) ]

Gene ID: 64144, updated on 6-Jun-2024

Summary

Official Symbol
Mllt1provided by MGI
Official Full Name
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1provided by MGI
Primary source
MGI:MGI:1927238
See related
Ensembl:ENSMUSG00000024212 AllianceGenome:MGI:1927238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ENL; BAM11; LTG19
Summary
Acts upstream of or within negative regulation of protein kinase activity. Located in nucleus. Is expressed in several structures, including brain; branchial arch; limb; maxillary process; and sensory organ. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 43.0), ovary adult (RPKM 41.6) and 28 other tissues See more
Orthologs
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Genomic context

See Mllt1 in Genome Data Viewer
Location:
17 D; 17 29.56 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57199611..57242497, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56892608..56935509, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase bubblegum family member 2 Neighboring gene STARR-seq mESC enhancer starr_42911 Neighboring gene acyl-CoA synthetase bubblegum family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1946 Neighboring gene alkaline ceramidase 1 Neighboring gene predicted gene, 33509

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein ENL
Names
leukemia-associated protein MLLT1
myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog
myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
trithorax

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410196.1NP_001397125.1  protein ENL isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073683
    UniProtKB/TrEMBL
    Q8CJ76
  2. NM_001410198.1NP_001397127.1  protein ENL isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC073683
  3. NM_022328.3NP_071723.1  protein ENL isoform 1

    See identical proteins and their annotated locations for NP_071723.1

    Status: VALIDATED

    Source sequence(s)
    AC073683
    Consensus CDS
    CCDS28918.1
    UniProtKB/TrEMBL
    Q8CJ76, Q9ERL0
    Related
    ENSMUSP00000025053.9, ENSMUST00000025053.10
    Conserved Domains (2) summary
    pfam03366
    Location:29109
    YEATS; YEATS family
    pfam05110
    Location:152335
    AF-4; AF-4 proto-oncoprotein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57199611..57242497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)