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Ctsz cathepsin Z [ Mus musculus (house mouse) ]

Gene ID: 64138, updated on 8-Feb-2024

Summary

Official Symbol
Ctszprovided by MGI
Official Full Name
cathepsin Zprovided by MGI
Primary source
MGI:MGI:1891190
See related
Ensembl:ENSMUSG00000016256 AllianceGenome:MGI:1891190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTSX; D2Wsu143e
Summary
This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature enzyme with carboxypeptidase activity. An enzymatically inactive form of the protein, that is associated with the propeptide, may be involved in cancer cell invasion and proliferation. Homozygous knockout mice for this gene exhibit impaired cancer cell invasion in a breast cancer model. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in placenta adult (RPKM 212.4), duodenum adult (RPKM 161.8) and 27 other tissues See more
Orthologs
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Genomic context

See Ctsz in Genome Data Viewer
Location:
2 H4; 2 97.94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (174269287..174280832, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (174427494..174439039, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06635 Neighboring gene GNAS antisense RNA 1 Neighboring gene STARR-seq mESC enhancer starr_06637 Neighboring gene GNAS complex locus Neighboring gene STARR-seq mESC enhancer starr_06638 Neighboring gene STARR-positive B cell enhancer ABC_E10168 Neighboring gene predicted gene, 30189 Neighboring gene STARR-positive B cell enhancer ABC_E1611 Neighboring gene STARR-positive B cell enhancer ABC_E1612 Neighboring gene negative elongation factor complex member C/D, Th1l Neighboring gene STARR-positive B cell enhancer ABC_E6030 Neighboring gene ribosomal protein L30, pseudogene 5 Neighboring gene tubulin, beta 1 class VI

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in epithelial tube branching involved in lung morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cathepsin Z
Names
cathepsin X
NP_071720.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022325.5NP_071720.1  cathepsin Z preproprotein

    See identical proteins and their annotated locations for NP_071720.1

    Status: REVIEWED

    Source sequence(s)
    AI834947, AK159618, AL844534, BY319344
    Consensus CDS
    CCDS17152.1
    UniProtKB/Swiss-Prot
    Q9WUU7
    UniProtKB/TrEMBL
    Q545I6, Q9ES94
    Related
    ENSMUSP00000016400.9, ENSMUST00000016400.9
    Conserved Domains (1) summary
    cd02698
    Location:64305
    Peptidase_C1A_CathepsinX; Cathepsin X; the only papain-like lysosomal cysteine peptidase exhibiting carboxymonopeptidase activity. It can also act as a carboxydipeptidase, like cathepsin B, but has been shown to preferentially cleave substrates through a monopeptidyl ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    174269287..174280832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)