Ctsz cathepsin Z [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctszprovided by MGI
Official Full Name: cathepsin Zprovided by MGI
Primary source: MGI:MGI:1891190
See related: Ensembl:ENSMUSG00000016256 AllianceGenome:MGI:1891190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CTSX; D2Wsu143e
Summary: This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature enzyme with carboxypeptidase activity. An enzymatically inactive form of the protein, that is associated with the propeptide, may be involved in cancer cell invasion and proliferation. Homozygous knockout mice for this gene exhibit impaired cancer cell invasion in a breast cancer model. [provided by RefSeq, Aug 2015]
Expression: Ubiquitous expression in placenta adult (RPKM 212.4), duodenum adult (RPKM 161.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 97.94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (174269287..174280832, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (174427494..174439039, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular cathepsin Z signals through the alpha5 integrin and augments NLRP3 inflammasome activation.
Title: Extracellular cathepsin Z signals through the α(5) integrin and augments NLRP3 inflammasome activation.
Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy.
Title: Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy.
Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.
Title: Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.
The data support a novel role for cathepsin Z in the propagation of IL-1beta-driven neuroinflammation.
Title: A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis.
nigericin-induced cell death depended partly on a single cathepsin, cathepsin X.
Title: Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.
tumor proliferation was exclusively regulated by cancer cell-intrinsic functions of CtsZ, whereas tumor invasion required contributions from both macrophages and cancer cell
Title: Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.
Our data show an active role for Ctsz in chronic inflammation and the development of gastric metaplasia.
Title: Induction of premalignant host responses by cathepsin x/z-deficiency in Helicobacter pylori-infected mice.
Plaque-associated microglial cells express gamma-enolase and cathepsin X.
Title: Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X.
Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.
Title: Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.
cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma
Title: Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125743 (e-PCR)
- UniSTS:142374

AI787083 (e-PCR)
- UniSTS:178788

RH136301 (e-PCR)
- UniSTS:210293

RH126244 (e-PCR)
- UniSTS:162952

Ctsz (e-PCR), detects polymorphism
- UniSTS:502680

RH124643 (e-PCR)
- UniSTS:161465

Homology

Homologs of the Ctsz gene: The Ctsz gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, C.elegans, and frog.
Orthologs from Annotation Pipeline: 473 organisms have orthologs with human gene Ctsz
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial tube branching involved in lung morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of neuron death	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cathepsin Z

Names: cathepsin X

NP_071720.1

EC 3.4.18.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022325.5 → NP_071720.1 cathepsin Z preproprotein

See identical proteins and their annotated locations for NP_071720.1

Status: REVIEWED

Source sequence(s)

AI834947, AK159618, AL844534, BY319344

Consensus CDS

CCDS17152.1

UniProtKB/Swiss-Prot

Q9WUU7

UniProtKB/TrEMBL

Q545I6

Related

ENSMUSP00000016400.9, ENSMUST00000016400.9

Conserved Domains (1) summary

cd02698
Location:64 → 305

Peptidase_C1A_CathepsinX; Cathepsin X; the only papain-like lysosomal cysteine peptidase exhibiting carboxymonopeptidase activity. It can also act as a carboxydipeptidase, like cathepsin B, but has been shown to preferentially cleave substrates through a monopeptidyl ...