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ACOT6 acyl-CoA thioesterase 6 [ Homo sapiens (human) ]

Gene ID: 641372, updated on 25-Nov-2021

Summary

Official Symbol
ACOT6provided by HGNC
Official Full Name
acyl-CoA thioesterase 6provided by HGNC
Primary source
HGNC:HGNC:33159
See related
Ensembl:ENSG00000205669 MIM:614267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf42; c14_5530
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ACOT6 in Genome Data Viewer
Location:
14q24.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (73610945..73619888)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74077649..74086592)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA-Lys (TTT) 14-1 Neighboring gene acyl-CoA thioesterase 4 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 pseudogene 1 Neighboring gene dynein axonemal light chain 1 Neighboring gene RNA, U6 small nuclear 240, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC161656, MGC161658

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 6
Names
putative acyl-CoA thioesterase 6
putative acyl-coenzyme A thioesterase 6
NP_001032239.1
NP_001352717.1
NP_001352718.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037162.1NP_001032239.1  acyl-coenzyme A thioesterase 6 isoform 2

    See identical proteins and their annotated locations for NP_001032239.1

    Status: VALIDATED

    Source sequence(s)
    DQ082756
    Consensus CDS
    CCDS32118.1
    UniProtKB/Swiss-Prot
    Q3I5F7
    Related
    ENSP00000370531.1, ENST00000381139.1
    Conserved Domains (1) summary
    pfam08840
    Location:1198
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
  2. NM_001365788.1NP_001352717.1  acyl-coenzyme A thioesterase 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005225
    Related
    ENSP00000496277.1, ENST00000645972.2
    Conserved Domains (2) summary
    pfam04775
    Location:16136
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:203412
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
  3. NM_001365789.1NP_001352718.1  acyl-coenzyme A thioesterase 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005225
    Related
    ENSP00000451464.1, ENST00000554229.1
    Conserved Domains (1) summary
    pfam08840
    Location:1198
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    73610945..73619888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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