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ZNF674 zinc finger protein 674 [ Homo sapiens (human) ]

Gene ID: 641339, updated on 8-Dec-2022

Summary

Official Symbol
ZNF674provided by HGNC
Official Full Name
zinc finger protein 674provided by HGNC
Primary source
HGNC:HGNC:17625
See related
Ensembl:ENSG00000251192 MIM:300573; AllianceGenome:HGNC:17625
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRX92; ZNF673B
Summary
This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked cognitive disabilities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in brain (RPKM 1.3), prostate (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF674 in Genome Data Viewer
Location:
Xp11.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (46497725..46545421, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (45904681..45952389, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (46357160..46404856, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 65 Neighboring gene KRAB box domain containing 4 Neighboring gene VEZT pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 50, pseudogene Neighboring gene ZNF674 antisense RNA 1 (head to head) Neighboring gene marker of proliferation Ki-67 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2012-08-29)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2012-08-29)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686H0940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 674
Names
zinc finger family member 674

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023376.2 RefSeqGene

    Range
    5037..52733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039891.3NP_001034980.1  zinc finger protein 674 isoform 1

    See identical proteins and their annotated locations for NP_001034980.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL031393, AW173662, AY971607, BQ417100
    Consensus CDS
    CCDS48099.1
    UniProtKB/Swiss-Prot
    E9PHQ4, Q2M3X9
    Related
    ENSP00000429148.1, ENST00000523374.5
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:190580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226246
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:280302
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:399423
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001146291.2NP_001139763.1  zinc finger protein 674 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame donor and acceptor splice sites at two coding exons compared to variant 1, resulting in an isoform (2), which is 6 aa shorter than isoform 1.
    Source sequence(s)
    AL031393, AW173662, AY971607, BQ417100, DA195605
    Consensus CDS
    CCDS55406.1
    UniProtKB/Swiss-Prot
    Q2M3X9
    Related
    ENSP00000428248.1, ENST00000414387.6
    Conserved Domains (3) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:184574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220240
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001190417.2NP_001177346.1  zinc finger protein 674 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site at a coding exon, compared to variant 1, resulting in an isoform (3), which is 5 aa shorter than isoform 1.
    Source sequence(s)
    AL031393, AW173662, AY971607, DC317540
    Consensus CDS
    CCDS94605.1
    UniProtKB/Swiss-Prot
    Q2M3X9
    UniProtKB/TrEMBL
    A0A804HHU7
    Related
    ENSP00000506769.1, ENST00000683375.1
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:185575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:221241
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:275297
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:394418
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    46497725..46545421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543943.4XP_011542245.1  zinc finger protein 674 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:189579
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:225245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279301
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:398422
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    45904681..45952389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)