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ADGRL4 adhesion G protein-coupled receptor L4 [ Homo sapiens (human) ]

Gene ID: 64123, updated on 1-Jun-2020

Summary

Official Symbol
ADGRL4provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L4provided by HGNC
Primary source
HGNC:HGNC:20822
See related
Ensembl:ENSG00000162618 MIM:616419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETL; ELTD1; KPG_003
Expression
Broad expression in fat (RPKM 38.7), spleen (RPKM 20.4) and 20 other tissues See more
Orthologs

Genomic context

See ADGRL4 in Genome Data Viewer
Location:
1p31.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (78889764..79006730, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (79355449..79472495, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23 pseudogene 3 Neighboring gene SNW domain containing 1 pseudogene Neighboring gene VISTA enhancer hs1989 Neighboring gene phosphoserine aminotransferase 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor L4
Names
EGF, latrophilin and seven transmembrane domain containing 1
EGF, latrophilin and seven transmembrane domain-containing protein 1
EGF-TM7-latrophilin-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022159.4NP_071442.2  adhesion G protein-coupled receptor L4 precursor

    See identical proteins and their annotated locations for NP_071442.2

    Status: VALIDATED

    Source sequence(s)
    AB032017, AC099674, AK129766, DA477962
    Consensus CDS
    CCDS41352.1
    UniProtKB/Swiss-Prot
    Q9HBW9
    Related
    ENSP00000359778.3, ENST00000370742.4
    Conserved Domains (4) summary
    pfam01825
    Location:368412
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:5891
    EGF_CA; Calcium-binding EGF domain
    pfam16489
    Location:139330
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl21561
    Location:424660
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    78889764..79006730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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