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ADGRL4 adhesion G protein-coupled receptor L4 [ Homo sapiens (human) ]

Gene ID: 64123, updated on 3-May-2025
Official Symbol
ADGRL4provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L4provided by HGNC
Primary source
HGNC:HGNC:20822
See related
Ensembl:ENSG00000162618 MIM:616419; AllianceGenome:HGNC:20822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETL; ELTD1; KPG_003
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Biomarker of glioblastoma and hypertrophic cardiomyopathy. [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in fat (RPKM 38.7), spleen (RPKM 20.4) and 20 other tissues See more
Orthologs
mouse all
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See ADGRL4 in Genome Data Viewer
Location:
1p31.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (78889764..79006730, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (78728626..78845196, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (79355449..79472415, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:79262697-79263301 Neighboring gene uncharacterized LOC124904203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1238 Neighboring gene VISTA enhancer hs1989 Neighboring gene phosphoserine aminotransferase 1 pseudogene 3 Neighboring gene uncharacterized LOC107984998 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:79603859-79604407

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression. Sheldon H, et al. Mol Cancer Res, 2021 Nov. PMID 34348993, Free PMC Article
  2. Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling. Favara DM, et al. Sci Rep, 2021 Apr 23. PMID 33893326, Free PMC Article
  3. Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion. Guihurt Santiago J, et al. BMC Cancer, 2021 Jan 11. PMID 33430814, Free PMC Article
  4. ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype. Sheldon H, et al. Int J Mol Sci, 2021 Oct 19. PMID 34681953, Free PMC Article
  5. A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Masiero M, et al. Cancer Cell, 2013 Aug 12. PMID 23871637, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression.
    Title: ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression.
  2. ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
    Title: ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
  3. ELTD1 promotes invasion and metastasis by activating MMP2 in colorectal cancer.
    Title: ELTD1 promotes invasion and metastasis by activating MMP2 in colorectal cancer.
  4. ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype.
    Title: ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype.
  5. Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling.
    Title: Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling.
  6. Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion.
    Title: Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion.
  7. ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1alpha signaling axis.
    Title: ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1α signaling axis.
  8. High ELTD1 expression is associated with glioma.
    Title: ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.
  9. miR-139-5p suppresses glioblastoma multiforme cell proliferation by targeting ELTD1 and regulating cell cycle.
    Title: MicroRNA-139-5p acts as a tumor suppressor by targeting ELTD1 and regulating cell cycle in glioblastoma multiforme.
  10. Results provide insight into the regulation of tumor angiogenesis and highlight ELTD1 as key player in blood vessel formation.
    Title: A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
adhesion G protein-coupled receptor L4
Names
EGF, latrophilin and seven transmembrane domain containing 1
EGF, latrophilin and seven transmembrane domain-containing protein 1
EGF-TM7-latrophilin-related protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022159.4 → NP_071442.2  adhesion G protein-coupled receptor L4 precursor

    See identical proteins and their annotated locations for NP_071442.2

    Status: VALIDATED

    Source sequence(s)
    AB032017, AC099674, AK129766, DA477962
    Consensus CDS
    CCDS41352.1
    UniProtKB/Swiss-Prot
    B1AR71, Q5KU34, Q9HBW9
    UniProtKB/TrEMBL
    A8KA29
    Related
    ENSP00000359778.3, ENST00000370742.4
    Conserved Domains (4) summary
    pfam01825
    Location:368 → 412
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:58 → 91
    EGF_CA; Calcium-binding EGF domain
    pfam16489
    Location:139 → 330
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl21561
    Location:424 → 660
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    78889764..79006730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    78728626..78845196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBW9.3 GenPept UniProtKB/Swiss-Prot:Q9HBW9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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