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ADGRL4 adhesion G protein-coupled receptor L4 [ Homo sapiens (human) ]

Gene ID: 64123, updated on 3-May-2025
Official Symbol
ADGRL4provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L4provided by HGNC
Primary source
HGNC:HGNC:20822
See related
Ensembl:ENSG00000162618 MIM:616419; AllianceGenome:HGNC:20822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETL; ELTD1; KPG_003
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Biomarker of glioblastoma and hypertrophic cardiomyopathy. [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in fat (RPKM 38.7), spleen (RPKM 20.4) and 20 other tissues See more
Orthologs
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See ADGRL4 in Genome Data Viewer
Location:
1p31.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (78889764..79006730, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (78728626..78845196, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (79355449..79472415, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:79262697-79263301 Neighboring gene uncharacterized LOC124904203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1238 Neighboring gene VISTA enhancer hs1989 Neighboring gene phosphoserine aminotransferase 1 pseudogene 3 Neighboring gene uncharacterized LOC107984998 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:79603859-79604407

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
adhesion G protein-coupled receptor L4
Names
EGF, latrophilin and seven transmembrane domain containing 1
EGF, latrophilin and seven transmembrane domain-containing protein 1
EGF-TM7-latrophilin-related protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022159.4NP_071442.2  adhesion G protein-coupled receptor L4 precursor

    See identical proteins and their annotated locations for NP_071442.2

    Status: VALIDATED

    Source sequence(s)
    AB032017, AC099674, AK129766, DA477962
    Consensus CDS
    CCDS41352.1
    UniProtKB/Swiss-Prot
    B1AR71, Q5KU34, Q9HBW9
    UniProtKB/TrEMBL
    A8KA29
    Related
    ENSP00000359778.3, ENST00000370742.4
    Conserved Domains (4) summary
    pfam01825
    Location:368412
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:5891
    EGF_CA; Calcium-binding EGF domain
    pfam16489
    Location:139330
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl21561
    Location:424660
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    78889764..79006730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    78728626..78845196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)