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FN3K fructosamine 3 kinase [ Homo sapiens (human) ]

Gene ID: 64122, updated on 1-Jun-2020

Summary

Official Symbol
FN3Kprovided by HGNC
Official Full Name
fructosamine 3 kinaseprovided by HGNC
Primary source
HGNC:HGNC:24822
See related
Ensembl:ENSG00000167363 MIM:608425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]
Expression
Broad expression in kidney (RPKM 47.7), brain (RPKM 22.0) and 20 other tissues See more
Orthologs

Genomic context

See FN3K in Genome Data Viewer
Location:
17q25.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (82735615..82751196)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80693452..80709073)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929552 Neighboring gene fructosamine 3 kinase related protein Neighboring gene Sharpr-MPRA regulatory region 591 Neighboring gene tubulin folding cofactor D Neighboring gene zinc finger protein 750

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry.
NHGRI GWA Catalog
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
NHGRI GWA Catalog
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
fructosamine-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructosamine-3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
fructosamine-3-kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity TAS
Traceable Author Statement
more info
 
protein-fructosamine 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein-ribulosamine 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
fructosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructoselysine metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein deglycation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fructosamine-3-kinase
Names
protein-psicosamine 3-kinase FN3K
protein-ribulosamine 3-kinase FN3K
NP_071441.1
XP_024306640.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022158.4NP_071441.1  fructosamine-3-kinase

    See identical proteins and their annotated locations for NP_071441.1

    Status: VALIDATED

    Source sequence(s)
    AC024361
    Consensus CDS
    CCDS11818.1
    UniProtKB/Swiss-Prot
    Q9H479
    Related
    ENSP00000300784.7, ENST00000300784.8
    Conserved Domains (1) summary
    cl21453
    Location:21309
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    82735615..82751196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450872.1XP_024306640.1  fructosamine-3-kinase isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
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