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Moap1 modulator of apoptosis 1 [ Mus musculus (house mouse) ]

Gene ID: 64113, updated on 26-Sep-2022

Summary

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Official Symbol
Moap1provided by MGI
Official Full Name
modulator of apoptosis 1provided by MGI
Primary source
MGI:MGI:1915555
See related
Ensembl:ENSMUSG00000096458 AllianceGenome:MGI:1915555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Map-1; Pnma4; MmMOAP1
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in apoptotic signaling pathway; positive regulation of apoptotic process; and positive regulation of release of cytochrome c from mitochondria. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol; mitochondrial outer membrane; and nucleus. Is expressed in nervous system and sensory organ. Orthologous to human MOAP1 (modulator of apoptosis 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 10.8), testis adult (RPKM 9.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Moap1 in Genome Data Viewer
Location:
12; 12 E
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102706089..102709920, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102739830..102743661, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene inositol 1,3,4-triphosphate 5/6 kinase Neighboring gene VISTA enhancer mm491 Neighboring gene predicted gene, 30296 Neighboring gene predicted gene 20604 Neighboring gene lysosomal enzyme trafficking factor Neighboring gene GON7 subunit of KEOPS complex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of Apoptosis 1-Deficient Mice. Zhao H, et al. Mol Neurobiol, 2019 Mar. PMID 30003515, Free PMC Article
  2. MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria. Tan CT, et al. Cell Rep, 2016 Jun 28. PMID 27320914
  3. MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling. Tan CT, et al. EMBO Rep, 2021 Jan 7. PMID 33393215, Free PMC Article
  4. RASSF6 is a novel member of the RASSF family of tumor suppressors. Allen NP, et al. Oncogene, 2007 Sep 13. PMID 17404571
  5. The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore. Chang HC, et al. Autophagy, 2021 Nov. PMID 33783314, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
    Title: MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
  2. These data suggest that MOAP-1 is required in the regulation of stress response in the dorsal raphe nucleus. Crosstalk between BDNF and 5-HT appears to play an important role in this stress response.
    Title: Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of Apoptosis 1-Deficient Mice.
  3. These findings reveal a role for MOAP-1 in Fas signaling in the liver by promoting MTCH2-mediated tBid recruitment to mitochondria.
    Title: MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria.
  4. MAP-1 is a direct mitochondrial target of Bax.
    Title: MAP-1 is a mitochondrial effector of Bax.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough Gm20604

Readthrough gene: Gm20604, Included gene: Gon7

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into mitochondrial membrane involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
modulator of apoptosis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142937.2 → NP_001136409.1  modulator of apoptosis 1

    See identical proteins and their annotated locations for NP_001136409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC132315, AU080670
    Consensus CDS
    CCDS26122.1
    UniProtKB/Swiss-Prot
    Q9ERH6
    Related
    ENSMUSP00000137010.2, ENSMUST00000178384.2
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 327
    PNMA

  2. NM_022323.7 → NP_071718.1  modulator of apoptosis 1

    See identical proteins and their annotated locations for NP_071718.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC132315, BU614788
    Consensus CDS
    CCDS26122.1
    UniProtKB/Swiss-Prot
    Q9ERH6
    Related
    ENSMUSP00000133459.3, ENSMUST00000173760.9
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 327
    PNMA

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    102706089..102709920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERH6.1 GenPept UniProtKB/Swiss-Prot:Q9ERH6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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