Format

Send to:

Choose Destination

MOAP1 modulator of apoptosis 1 [ Homo sapiens (human) ]

Gene ID: 64112, updated on 10-May-2020

Summary

Official Symbol
MOAP1provided by HGNC
Official Full Name
modulator of apoptosis 1provided by HGNC
Primary source
HGNC:HGNC:16658
See related
Ensembl:ENSG00000165943 MIM:609485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP-1; PNMA4
Summary
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 65.7), heart (RPKM 21.0) and 24 other tissues See more
Orthologs

Genomic context

See MOAP1 in Genome Data Viewer
Location:
14q32.12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (93182199..93184897, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93648541..93651249, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene inositol-tetrakisphosphate 1-kinase Neighboring gene ITPK1 antisense RNA 1 Neighboring gene cytochrome b5 type A pseudogene 3 Neighboring gene transmembrane protein 251 Neighboring gene GON7 subunit of KEOPS complex Neighboring gene ubiquitin protein ligase E3 component n-recognin 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study link novel loci to endometriosis.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
modulator of apoptosis 1
Names
MAP1
paraneoplastic Ma antigen family member 4
paraneoplastic antigen Ma4
paraneoplastic antigen like 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022151.5NP_071434.2  modulator of apoptosis 1

    See identical proteins and their annotated locations for NP_071434.2

    Status: REVIEWED

    Source sequence(s)
    BC015044, BG699993
    Consensus CDS
    CCDS9908.1
    UniProtKB/Swiss-Prot
    Q96BY2
    Related
    ENSP00000298894.4, ENST00000298894.5
    Conserved Domains (1) summary
    pfam14893
    Location:1325
    PNMA; PNMA

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    93182199..93184897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    296761..299459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center