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CENPK centromere protein K [ Homo sapiens (human) ]

Gene ID: 64105, updated on 17-Jun-2019

Summary

Official Symbol
CENPKprovided by HGNC
Official Full Name
centromere protein Kprovided by HGNC
Primary source
HGNC:HGNC:29479
See related
Ensembl:ENSG00000123219 MIM:611502
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P33; Solt; CENP-K; FKSG14; AF5alpha
Summary
CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 1.8), bone marrow (RPKM 1.7) and 19 other tissues See more
Orthologs

Genomic context

See CENPK in Genome Data Viewer
Location:
5q12.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (65488919..65563194, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (64813593..64858995, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 6 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 1 Neighboring gene ribosomal protein S2 pseudogene 23 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene RNA, U6 small nuclear 540, pseudogene Neighboring gene tripartite motif containing 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of centromere protein K (CENPK) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Chromosome Maintenance, organism-specific biosystem (from REACTOME)
    Chromosome Maintenance, organism-specific biosystemChromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.
  • Deposition of new CENPA-containing nucleosomes at the centromere, organism-specific biosystem (from REACTOME)
    Deposition of new CENPA-containing nucleosomes at the centromere, organism-specific biosystemEukaryotic centromeres are marked by a unique form of histone H3, designated CENPA in humans. In human cells newly synthesized CENPA is deposited in nucleosomes at the centromere during late telophas...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Nucleosome assembly, organism-specific biosystem (from REACTOME)
    Nucleosome assembly, organism-specific biosystemThe formation of centromeric chromatin assembly outside the context of DNA replication involves the assembly of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A).
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
kinetochore assembly IEA
Inferred from Electronic Annotation
more info
 
mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
condensed nuclear chromosome inner kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
centromere protein K
Names
SoxLZ/Sox6-binding protein Solt
interphase centromere complex protein 37
leucine zipper protein FKSG14
protein AF-5alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267038.2NP_001253967.1  centromere protein K isoform 1

    See identical proteins and their annotated locations for NP_001253967.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC005400, BC008504, BG502832
    Consensus CDS
    CCDS3984.1
    UniProtKB/Swiss-Prot
    Q9BS16
    Related
    ENSP00000422421.1, ENST00000514814.5
    Conserved Domains (1) summary
    pfam11802
    Location:10269
    CENP-K; Centromere-associated protein K
  2. NM_001349367.2NP_001336296.1  centromere protein K isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in its 5' coding region, resulting in use of an alternate start codon, compared to variant 1. The encoded isoform (3) has a slightly longer, but distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC005400, BC008504, BG502832, BG527280
    Conserved Domains (1) summary
    pfam11802
    Location:12271
    CENP-K; Centromere-associated protein K
  3. NM_001349368.2NP_001336297.1  centromere protein K isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and lacks an alternate in-frame exon in its central coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    BC005400, BC008504, BF211376, BG502832, BG505115
    Consensus CDS
    CCDS87299.1
    Conserved Domains (1) summary
    pfam11802
    Location:1206
    CENP-K; Centromere-associated protein K
  4. NM_001349369.2NP_001336298.1  centromere protein K isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and contains an alternate terminal exon, resulting in a novel 3' coding region, compared to variant 1. The encoded isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC016620, BC005400, BG502832, BG505115
    Conserved Domains (1) summary
    pfam11802
    Location:1189
    CENP-K; Centromere-associated protein K
  5. NM_022145.5NP_071428.2  centromere protein K isoform 1

    See identical proteins and their annotated locations for NP_071428.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC008504
    Consensus CDS
    CCDS3984.1
    UniProtKB/Swiss-Prot
    Q9BS16
    Related
    ENSP00000379911.1, ENST00000396679.6
    Conserved Domains (1) summary
    pfam11802
    Location:10269
    CENP-K; Centromere-associated protein K

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    65488919..65563194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009693.1XP_016865182.1  centromere protein K isoform X3

  2. XM_017009696.2XP_016865185.1  centromere protein K isoform X9

  3. XM_011543540.2XP_011541842.1  centromere protein K isoform X8

    Conserved Domains (1) summary
    pfam11802
    Location:12221
    CENP-K; Centromere-associated protein K
  4. XM_024446144.1XP_024301912.1  centromere protein K isoform X10

    Conserved Domains (1) summary
    pfam11802
    Location:10219
    CENP-K; Centromere-associated protein K
  5. XM_017009695.1XP_016865184.1  centromere protein K isoform X6

  6. XM_011543538.2XP_011541840.1  centromere protein K isoform X5

    Conserved Domains (1) summary
    pfam11802
    Location:12238
    CENP-K; Centromere-associated protein K
  7. XM_024446148.1XP_024301916.1  centromere protein K isoform X14

    Conserved Domains (1) summary
    pfam11802
    Location:18172
    CENP-K; Centromere-associated protein K
  8. XM_011543541.2XP_011541843.1  centromere protein K isoform X12

    See identical proteins and their annotated locations for XP_011541843.1

    Conserved Domains (1) summary
    pfam11802
    Location:18205
    CENP-K; Centromere-associated protein K
  9. XM_017009697.1XP_016865186.1  centromere protein K isoform X11

  10. XM_011543537.2XP_011541839.1  centromere protein K isoform X4

    UniProtKB/TrEMBL
    D6RHD3
    Related
    ENSP00000421034.1, ENST00000508421.5
    Conserved Domains (1) summary
    pfam11802
    Location:1239
    CENP-K; Centromere-associated protein K
  11. XM_011543539.2XP_011541841.1  centromere protein K isoform X7

    Related
    ENSP00000425686.1, ENST00000510693.5
    Conserved Domains (1) summary
    pfam11802
    Location:10236
    CENP-K; Centromere-associated protein K
  12. XM_024446146.1XP_024301914.1  centromere protein K isoform X13

    Conserved Domains (1) summary
    pfam11802
    Location:4191
    CENP-K; Centromere-associated protein K
  13. XM_017009692.1XP_016865181.1  centromere protein K isoform X2

    UniProtKB/Swiss-Prot
    Q9BS16
    Conserved Domains (1) summary
    pfam11802
    Location:10269
    CENP-K; Centromere-associated protein K
  14. XM_017009690.1XP_016865179.1  centromere protein K isoform X2

    UniProtKB/Swiss-Prot
    Q9BS16
    Conserved Domains (1) summary
    pfam11802
    Location:10269
    CENP-K; Centromere-associated protein K
  15. XM_017009691.1XP_016865180.1  centromere protein K isoform X2

    UniProtKB/Swiss-Prot
    Q9BS16
    Related
    ENSP00000242872.3, ENST00000242872.7
    Conserved Domains (1) summary
    pfam11802
    Location:10269
    CENP-K; Centromere-associated protein K
  16. XM_024446145.1XP_024301913.1  centromere protein K isoform X12

    Conserved Domains (1) summary
    pfam11802
    Location:18205
    CENP-K; Centromere-associated protein K
  17. XM_024446147.1XP_024301915.1  centromere protein K isoform X13

    Conserved Domains (1) summary
    pfam11802
    Location:4191
    CENP-K; Centromere-associated protein K
  18. XM_011543542.2XP_011541844.1  centromere protein K isoform X12

    See identical proteins and their annotated locations for XP_011541844.1

    Conserved Domains (1) summary
    pfam11802
    Location:18205
    CENP-K; Centromere-associated protein K
  19. XM_011543535.2XP_011541837.1  centromere protein K isoform X1

    See identical proteins and their annotated locations for XP_011541837.1

    Conserved Domains (1) summary
    pfam11802
    Location:12271
    CENP-K; Centromere-associated protein K
  20. XM_011543536.2XP_011541838.1  centromere protein K isoform X2

    See identical proteins and their annotated locations for XP_011541838.1

    UniProtKB/Swiss-Prot
    Q9BS16
    Conserved Domains (1) summary
    pfam11802
    Location:10269
    CENP-K; Centromere-associated protein K
  21. XM_017009694.1XP_016865183.1  centromere protein K isoform X4

    UniProtKB/TrEMBL
    D6RHD3
    Conserved Domains (1) summary
    pfam11802
    Location:1239
    CENP-K; Centromere-associated protein K
  22. XM_017009701.1XP_016865190.1  centromere protein K isoform X15

RNA

  1. XR_001742177.1 RNA Sequence

  2. XR_948282.3 RNA Sequence

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