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LRRC4 leucine rich repeat containing 4 [ Homo sapiens (human) ]

Gene ID: 64101, updated on 7-Dec-2018

Summary

Official Symbol
LRRC4provided by HGNC
Official Full Name
leucine rich repeat containing 4provided by HGNC
Primary source
HGNC:HGNC:15586
See related
Ensembl:ENSG00000128594 MIM:610486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAG14; NGL-2
Summary
This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 14.4), adrenal (RPKM 3.2) and 12 other tissues See more
Orthologs

Genomic context

See LRRC4 in Genome Data Viewer
Location:
7q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (128027071..128032107, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127667124..127671002, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene CD2 cytoplasmic tail binding protein 2 pseudogene Neighboring gene uncharacterized LOC105375492 Neighboring gene SND1 intronic transcript 1 Neighboring gene uncharacterized LOC105375493 Neighboring gene microRNA 593

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133342, MGC133343

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density protein 95 clustering IEA
Inferred from Electronic Annotation
more info
 
regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
 
synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 4
Names
brain tumor associated protein LRRC4
brain tumor-associated protein BAG
nasopharyngeal carcinoma-associated gene 14 protein
netrin-G2 ligand

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022143.5NP_071426.1  leucine-rich repeat-containing protein 4 precursor

    See identical proteins and their annotated locations for NP_071426.1

    Status: VALIDATED

    Source sequence(s)
    AC008039, AF196976, BC111745, BU682120
    Consensus CDS
    CCDS5799.1
    UniProtKB/Swiss-Prot
    Q9HBW1
    Related
    ENSP00000249363.3, ENST00000249363.3
    Conserved Domains (5) summary
    smart00013
    Location:4679
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300351
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:359441
    IG; Immunoglobulin
    COG4886
    Location:74291
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:77100
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    128027071..128032107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516461.3XP_011514763.1  leucine-rich repeat-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011514763.1

    UniProtKB/Swiss-Prot
    Q9HBW1
    Conserved Domains (5) summary
    smart00013
    Location:4679
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300351
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:359441
    IG; Immunoglobulin
    COG4886
    Location:74291
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:77100
    LRR_RI; leucine-rich repeat [structural motif]
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