Format

Send to:

Choose Destination

ELSPBP1 epididymal sperm binding protein 1 [ Homo sapiens (human) ]

Gene ID: 64100, updated on 12-Oct-2019

Summary

Official Symbol
ELSPBP1provided by HGNC
Official Full Name
epididymal sperm binding protein 1provided by HGNC
Primary source
HGNC:HGNC:14417
See related
Ensembl:ENSG00000169393 MIM:607443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E12; HE12; EL149; EDDM12
Summary
The protein encoded by this gene belongs to the sperm-coating protein family of epididymal origin. This protein and its canine homolog are the first known examples of proteins with four tandemly arranged fibronectin type 2 (Fn2) domains in the Fn2-module protein family. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See ELSPBP1 in Genome Data Viewer
Location:
19q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (47994632..48025154)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48497908..48528410)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small NF90 (ILF3) associated RNA C1 Neighboring gene binder of sperm protein homolog 1 Neighboring gene calcium binding protein 5 Neighboring gene phospholipase A2 group IVC Neighboring gene PLA2G4C antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
single fertilization IEA
Inferred from Electronic Annotation
more info
 
sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
epididymal sperm-binding protein 1
Names
epididymal protein 12
epididymal secretory protein 12
epididymis luminal secretory protein 149
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022142.5NP_071425.3  epididymal sperm-binding protein 1 precursor

    See identical proteins and their annotated locations for NP_071425.3

    Status: REVIEWED

    Source sequence(s)
    AC010330, AF279147, BM661759, BM663735
    Consensus CDS
    CCDS12708.1
    UniProtKB/Swiss-Prot
    Q96BH3
    Related
    ENSP00000340660.2, ENST00000339841.7
    Conserved Domains (2) summary
    cd00062
    Location:177223
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    pfam00040
    Location:74115
    fn2; Fibronectin type II domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    47994632..48025154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027130.1XP_016882619.1  epididymal sperm-binding protein 1 isoform X1

Support Center