Format

Send to:

Choose Destination

PARVG parvin gamma [ Homo sapiens (human) ]

Gene ID: 64098, updated on 1-Aug-2020

Summary

Official Symbol
PARVGprovided by HGNC
Official Full Name
parvin gammaprovided by HGNC
Primary source
HGNC:HGNC:14654
See related
Ensembl:ENSG00000138964 MIM:608122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Members of the parvin family, including PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM, Aug 2004]
Expression
Broad expression in spleen (RPKM 17.3), bone marrow (RPKM 16.9) and 19 other tissues See more
Orthologs

Genomic context

See PARVG in Genome Data Viewer
Location:
22q13.31
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (44170228..44208469)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (44566271..44604349)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene 36 Neighboring gene SAMM50 sorting and assembly machinery component Neighboring gene uncharacterized LOC107987326 Neighboring gene parvin beta Neighboring gene uncharacterized LOC107985570 Neighboring gene uncharacterized LOC107985571 Neighboring gene shisa like 1 Neighboring gene uncharacterized LOC101927499

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137605.2NP_001131077.1  gamma-parvin

    See identical proteins and their annotated locations for NP_001131077.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. This variant lacks full-length support and thus it has an inferred exon combination; the alternate 5' exon, which extends the gene range, is well-supported by partial transcript data.
    Source sequence(s)
    AF237772, AI075834, AL031595, BP299653
    UniProtKB/Swiss-Prot
    Q9HBI0
    UniProtKB/TrEMBL
    A0A024R4U4
    Related
    ENSP00000391453.1, ENST00000422871.5
    Conserved Domains (1) summary
    pfam00307
    Location:44151
    CH; Calponin homology (CH) domain
  2. NM_022141.7NP_071424.1  gamma-parvin

    See identical proteins and their annotated locations for NP_071424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI075834, AL031595, BC034406, DA673498
    Consensus CDS
    CCDS14057.1
    UniProtKB/Swiss-Prot
    Q9HBI0
    UniProtKB/TrEMBL
    A0A024R4U4
    Related
    ENSP00000391583.2, ENST00000444313.8
    Conserved Domains (1) summary
    pfam00307
    Location:44151
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    44170228..44208469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530302.2XP_011528604.1  gamma-parvin isoform X1

    See identical proteins and their annotated locations for XP_011528604.1

    Conserved Domains (1) summary
    pfam00307
    Location:279379
    CH; Calponin homology (CH) domain
  2. XM_017028907.1XP_016884396.1  gamma-parvin isoform X3

    Related
    ENST00000475485.6
  3. XM_005261702.3XP_005261759.1  gamma-parvin isoform X2

    See identical proteins and their annotated locations for XP_005261759.1

    UniProtKB/Swiss-Prot
    Q9HBI0
    UniProtKB/TrEMBL
    A0A024R4U4
    Conserved Domains (1) summary
    pfam00307
    Location:44151
    CH; Calponin homology (CH) domain
  4. XM_017028908.1XP_016884397.1  gamma-parvin isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001137606.1: Suppressed sequence

    Description
    NM_001137606.1: This RefSeq was permanently suppressed because currently there is insufficient support for the full-length nature of this variant.
  2. NM_001254741.1: Suppressed sequence

    Description
    NM_001254741.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the 3' end represents retained intron.
  3. NM_001254742.1: Suppressed sequence

    Description
    NM_001254742.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the 3' end represents retained intron.
  4. NM_001254743.1: Suppressed sequence

    Description
    NM_001254743.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the 3' end represents retained intron.
Support Center