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RBKS ribokinase [ Homo sapiens (human) ]

Gene ID: 64080, updated on 12-Oct-2019

Summary

Official Symbol
RBKSprovided by HGNC
Official Full Name
ribokinaseprovided by HGNC
Primary source
HGNC:HGNC:30325
See related
Ensembl:ENSG00000171174 MIM:611132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RK; RBSK
Summary
This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Broad expression in adrenal (RPKM 7.1), small intestine (RPKM 6.5) and 22 other tissues See more
Orthologs

Genomic context

See RBKS in Genome Data Viewer
Location:
2p23.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27781364..27890396, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (28004266..28113223, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374378 Neighboring gene mitochondrial ribosomal protein L33 Neighboring gene chromosome 12 open reading frame 10 pseudogene Neighboring gene BABAM2 antisense RNA 1 Neighboring gene BRISC and BRCA1 A complex member 2 Neighboring gene uncharacterized LOC105374369

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Pentose phosphate pathway, organism-specific biosystem (from KEGG)
    Pentose phosphate pathway, organism-specific biosystemThe pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathwa...
  • Pentose phosphate pathway, conserved biosystem (from KEGG)
    Pentose phosphate pathway, conserved biosystemThe pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathwa...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 5230400M11Rik, DKFZp686G13268

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribokinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
D-ribose catabolic process IEA
Inferred from Electronic Annotation
more info
 
carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
pentose-phosphate shunt TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribokinase
NP_001274509.1
NP_071411.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287580.1NP_001274509.1  ribokinase isoform 2

    See identical proteins and their annotated locations for NP_001274509.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC021171, AJ404857, BC017425, BF436282, BX648909
    UniProtKB/Swiss-Prot
    Q9H477
    Conserved Domains (1) summary
    cl00192
    Location:1251
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  2. NM_022128.3NP_071411.1  ribokinase isoform 1

    See identical proteins and their annotated locations for NP_071411.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AJ404857, BC017425, BF436282
    Consensus CDS
    CCDS1762.1
    UniProtKB/Swiss-Prot
    Q9H477
    Related
    ENSP00000306817.3, ENST00000302188.8
    Conserved Domains (1) summary
    TIGR02152
    Location:22318
    D_ribokin_bact; ribokinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27781364..27890396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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