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C19orf33 chromosome 19 open reading frame 33 [ Homo sapiens (human) ]

Gene ID: 64073, updated on 23-Nov-2021

Summary

Official Symbol
C19orf33provided by HGNC
Official Full Name
chromosome 19 open reading frame 33provided by HGNC
Primary source
HGNC:HGNC:16668
See related
Ensembl:ENSG00000167644
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMUP; H2RSP; IMUP-1; IMUP-2
Summary
The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Biased expression in colon (RPKM 62.2), small intestine (RPKM 43.1) and 11 other tissues See more
Orthologs
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Genomic context

See C19orf33 in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38304251..38305006)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38794891..38795646)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14A Neighboring gene serine peptidase inhibitor, Kunitz type 2 Neighboring gene Yip1 interacting factor homolog B, membrane trafficking protein Neighboring gene potassium two pore domain channel subfamily K member 6 Neighboring gene Sharpr-MPRA regulatory region 11361 Neighboring gene cation channel sperm associated auxiliary subunit gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SPINT2

Homology

Clone Names

  • MGC39135, MGC75180

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
immortalization up-regulated protein
Names
HAI-2 related small protein
hepatocyte growth factor activator inhibitor type 2-related small protein
immortalization-upregulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317801.2NP_001304730.1  immortalization up-regulated protein isoform IMUP-2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (IMUP-2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC060319, CB109881
    Consensus CDS
    CCDS82344.1
    UniProtKB/Swiss-Prot
    Q9GZP8
    Related
    ENSP00000464940.1, ENST00000588605.5
    Conserved Domains (1) summary
    pfam15761
    Location:152
    IMUP; Immortalisation up-regulated protein
  2. NM_033520.3NP_277055.1  immortalization up-regulated protein isoform IMUP-1

    See identical proteins and their annotated locations for NP_277055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (IMUP-1).
    Source sequence(s)
    AF213678, CB109881
    Consensus CDS
    CCDS12511.1
    UniProtKB/Swiss-Prot
    Q9GZP8
    Related
    ENSP00000301246.4, ENST00000301246.10
    Conserved Domains (1) summary
    pfam15761
    Location:179
    IMUP; Immortalization up-regulated protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38304251..38305006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022125.1: Suppressed sequence

    Description
    NM_022125.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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