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OXCT2 3-oxoacid CoA-transferase 2 [ Homo sapiens (human) ]

Gene ID: 64064, updated on 17-Jun-2019

Summary

Official Symbol
OXCT2provided by HGNC
Official Full Name
3-oxoacid CoA-transferase 2provided by HGNC
Primary source
HGNC:HGNC:18606
See related
Ensembl:ENSG00000198754 MIM:610289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCOTT; FKSG25
Summary
The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. [provided by RefSeq, Aug 2016]
Orthologs

Genomic context

See OXCT2 in Genome Data Viewer
Location:
1p34.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (39769523..39771348, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40235197..40237020, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 121 pseudogene Neighboring gene peptidylprolyl isomerase E Neighboring gene bone morphogenetic protein 8b Neighboring gene BMP8B antisense RNA 1 Neighboring gene uncharacterized LOC101929536

Genomic regions, transcripts, and products

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00030

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-oxoacid CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ketone body catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
motile cilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
Names
3-oxoacid CoA-transferase 2A
testis-specific succinyl CoA:3-oxoacid CoA-transferase
NP_071403.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022120.2NP_071403.1  succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_071403.1

    Status: REVIEWED

    Source sequence(s)
    AL033527, AY013700
    Consensus CDS
    CCDS445.1
    UniProtKB/Swiss-Prot
    Q9BYC2
    Related
    ENSP00000361914.1, ENST00000327582.5
    Conserved Domains (3) summary
    COG1788
    Location:48274
    AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
    COG4670
    Location:48514
    YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]
    cl00339
    Location:297505
    SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    39769523..39771348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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