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PRSS22 serine protease 22 [ Homo sapiens (human) ]

Gene ID: 64063, updated on 13-Mar-2020

Summary

Official Symbol
PRSS22provided by HGNC
Official Full Name
serine protease 22provided by HGNC
Primary source
HGNC:HGNC:14368
See related
Ensembl:ENSG00000005001 MIM:609343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BSSP-4; SP001LA; hBSSP-4
Summary
This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 17.2), stomach (RPKM 8.5) and 11 other tissues See more
Orthologs

Genomic context

See PRSS22 in Genome Data Viewer
Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2852729..2858630, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2902728..2908625, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zymogen granule protein 16B Neighboring gene serine protease 30, pseudogene Neighboring gene uncharacterized LOC101929566 Neighboring gene FLYWCH family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC9599

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
brain-specific serine protease 4
Names
prosemin
protease, serine 22
protease, serine S1 family member 22
serine protease 26
tryptase epsilon

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046976.1 RefSeqGene

    Range
    5461..10901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022119.4NP_071402.1  brain-specific serine protease 4 precursor

    See identical proteins and their annotated locations for NP_071402.1

    Status: REVIEWED

    Source sequence(s)
    AF321182, AW083723, BQ893064
    Consensus CDS
    CCDS10481.1
    UniProtKB/Swiss-Prot
    Q9GZN4
    Related
    ENSP00000161006.3, ENST00000161006.8
    Conserved Domains (1) summary
    cd00190
    Location:50288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2852729..2858630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255473.3XP_005255530.1  brain-specific serine protease 4 isoform X1

    See identical proteins and their annotated locations for XP_005255530.1

    UniProtKB/Swiss-Prot
    Q9GZN4
    Conserved Domains (1) summary
    cd00190
    Location:50288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_013171812.1 Reference GRCh38.p13 PATCHES

    Range
    32208..37628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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