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RBM26 RNA binding motif protein 26 [ Homo sapiens (human) ]

Gene ID: 64062, updated on 13-May-2022

Summary

Official Symbol
RBM26provided by HGNC
Official Full Name
RNA binding motif protein 26provided by HGNC
Primary source
HGNC:HGNC:20327
See related
Ensembl:ENSG00000139746 AllianceGenome:HGNC:20327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARRS2; SE70-2; ZC3H17; PRO1777; C13orf10; PPP1R132
Summary
Enables RNA binding activity. Predicted to be involved in mRNA processing. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 9.9), testis (RPKM 9.9) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See RBM26 in Genome Data Viewer
Location:
13q31.1
Exon count:
24
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (79311827..79406255, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (78547111..78634324, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (79893003..79980390, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene NIPA2 pseudogene 5 Neighboring gene BCAS2 pseudogene 3 Neighboring gene RNA, 5S ribosomal pseudogene 33 Neighboring gene uncharacterized LOC105370274 Neighboring gene RBM26 antisense RNA 1 Neighboring gene NDFIP2 antisense RNA 1 Neighboring gene Nedd4 family interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated RNA binding motif protein 26 (RBM26) is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10092, FLJ14866, FLJ20957, MGC133295, MGC133296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein 26
Names
CTCL tumor antigen se70-2
acidic rich RS domain containing 2
cutaneous T-cell lymphoma tumor antigen se70-2
protein phosphatase 1, regulatory 132

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286631.2NP_001273560.1  RNA-binding protein 26 isoform 1

    See identical proteins and their annotated locations for NP_001273560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL139006, AL159974, BC111739, CF994811
    Consensus CDS
    CCDS73591.1
    UniProtKB/Swiss-Prot
    Q5T8P6
    UniProtKB/TrEMBL
    A0A087X0H9
    Related
    ENSP00000483408.1, ENST00000622611.4
    Conserved Domains (5) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    COG0419
    Location:724846
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd12258
    Location:888959
    RRM2_RBM26_like; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:536611
    RRM1_RBM26; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26)
    cl02562
    Location:1176
    PWI; PWI domain
  2. NM_001286632.2NP_001273561.1  RNA-binding protein 26 isoform 2

    See identical proteins and their annotated locations for NP_001273561.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses two alternate in-frame splice sites, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK302871, AL139006, AL159974, CF994811
    Consensus CDS
    CCDS66566.1
    UniProtKB/Swiss-Prot
    Q5T8P6
    Related
    ENSP00000390222.1, ENST00000438724.5
    Conserved Domains (5) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    COG0419
    Location:698820
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd12258
    Location:862933
    RRM2_RBM26_like; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:531606
    RRM1_RBM26; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26)
    cl02562
    Location:1176
    PWI; PWI domain
  3. NM_001366735.2NP_001353664.1  RNA-binding protein 26 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL139006, AL159974
    Related
    ENSP00000387531.2, ENST00000438737.3
    Conserved Domains (5) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    COG0419
    Location:722844
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd12258
    Location:886957
    RRM2_RBM26_like; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:531606
    RRM1_RBM26; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26)
    cl02562
    Location:1176
    PWI; PWI domain
  4. NM_022118.5NP_071401.3  RNA-binding protein 26 isoform 3

    See identical proteins and their annotated locations for NP_071401.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL139006, AL159974, BC041655, CF994811
    Consensus CDS
    CCDS9462.1
    UniProtKB/Swiss-Prot
    Q5T8P6
    Related
    ENSP00000267229.7, ENST00000267229.11
    Conserved Domains (5) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    COG0419
    Location:695817
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd12258
    Location:859930
    RRM2_RBM26_like; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:531606
    RRM1_RBM26; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26)
    cl02562
    Location:1176
    PWI; PWI domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    79311827..79406255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430536.1XP_047286492.1  RNA-binding protein 26 isoform X45

  2. XM_047430535.1XP_047286491.1  RNA-binding protein 26 isoform X44

  3. XM_047430521.1XP_047286477.1  RNA-binding protein 26 isoform X30

  4. XM_047430534.1XP_047286490.1  RNA-binding protein 26 isoform X43

  5. XM_047430533.1XP_047286489.1  RNA-binding protein 26 isoform X42

  6. XM_047430522.1XP_047286478.1  RNA-binding protein 26 isoform X31

  7. XM_047430519.1XP_047286475.1  RNA-binding protein 26 isoform X29

  8. XM_047430532.1XP_047286488.1  RNA-binding protein 26 isoform X41

  9. XM_047430531.1XP_047286487.1  RNA-binding protein 26 isoform X40

  10. XM_047430530.1XP_047286486.1  RNA-binding protein 26 isoform X39

  11. XM_047430516.1XP_047286472.1  RNA-binding protein 26 isoform X26

  12. XM_047430528.1XP_047286484.1  RNA-binding protein 26 isoform X37

  13. XM_047430514.1XP_047286470.1  RNA-binding protein 26 isoform X24

  14. XM_047430529.1XP_047286485.1  RNA-binding protein 26 isoform X38

  15. XM_047430527.1XP_047286483.1  RNA-binding protein 26 isoform X36

  16. XM_017020697.3XP_016876186.1  RNA-binding protein 26 isoform X21

  17. XM_047430511.1XP_047286467.1  RNA-binding protein 26 isoform X19

  18. XM_047430526.1XP_047286482.1  RNA-binding protein 26 isoform X35

  19. XM_047430525.1XP_047286481.1  RNA-binding protein 26 isoform X34

  20. XM_047430510.1XP_047286466.1  RNA-binding protein 26 isoform X17

  21. XM_047430524.1XP_047286480.1  RNA-binding protein 26 isoform X33

  22. XM_047430523.1XP_047286479.1  RNA-binding protein 26 isoform X32

  23. XM_006719857.3XP_006719920.1  RNA-binding protein 26 isoform X15

    Conserved Domains (5) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    COG0419
    Location:737859
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd12258
    Location:901972
    RRM2_RBM26_like; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:546621
    RRM1_RBM26; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26)
    cl02562
    Location:1176
    PWI; PWI domain
  24. XM_005266497.3XP_005266554.1  RNA-binding protein 26 isoform X14

    Conserved Domains (5) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    COG0419
    Location:737859
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd12258
    Location:901972
    RRM2_RBM26_like; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:546621
    RRM1_RBM26; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26)
    cl02562
    Location:1176
    PWI; PWI domain
  25. XM_047430507.1XP_047286463.1  RNA-binding protein 26 isoform X12

  26. XM_047430518.1XP_047286474.1  RNA-binding protein 26 isoform X28

  27. XM_047430517.1XP_047286473.1  RNA-binding protein 26 isoform X27

  28. XM_047430506.1XP_047286462.1  RNA-binding protein 26 isoform X10

  29. XM_047430515.1XP_047286471.1  RNA-binding protein 26 isoform X25

  30. XM_047430504.1XP_047286460.1  RNA-binding protein 26 isoform X9

  31. XM_047430513.1XP_047286469.1  RNA-binding protein 26 isoform X22

  32. XM_047430503.1XP_047286459.1  RNA-binding protein 26 isoform X6

  33. XM_047430512.1XP_047286468.1  RNA-binding protein 26 isoform X20

  34. XM_047430502.1XP_047286458.1  RNA-binding protein 26 isoform X5

  35. XM_047430509.1XP_047286465.1  RNA-binding protein 26 isoform X16

  36. XM_047430501.1XP_047286457.1  RNA-binding protein 26 isoform X2

  37. XM_047430508.1XP_047286464.1  RNA-binding protein 26 isoform X13

  38. XM_011535186.4XP_011533488.1  RNA-binding protein 26 isoform X11

    Conserved Domains (6) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    cd12258
    Location:886957
    RRM2_RBM26_like; RNA recognition motif 2 of vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:531606
    RRM1_RBM26; RNA recognition motif 1 of vertebrate RNA-binding protein 26 (RBM26)
    pfam08648
    Location:132165
    DUF1777; Protein of unknown function (DUF1777)
    pfam13864
    Location:738819
    Enkurin; Calmodulin-binding
    cl02562
    Location:1176
    PWI; PWI domain
  39. XM_011535184.3XP_011533486.1  RNA-binding protein 26 isoform X8

    Conserved Domains (5) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    COG0419
    Location:727849
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd12258
    Location:891962
    RRM2_RBM26_like; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:536611
    RRM1_RBM26; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26)
    cl02562
    Location:1176
    PWI; PWI domain
  40. XM_017020695.3XP_016876184.1  RNA-binding protein 26 isoform X23

  41. XM_017020689.3XP_016876178.1  RNA-binding protein 26 isoform X7

  42. XM_017020696.3XP_016876185.1  RNA-binding protein 26 isoform X18

  43. XM_011535182.3XP_011533484.1  RNA-binding protein 26 isoform X4

    Conserved Domains (5) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    COG0419
    Location:732854
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd12258
    Location:896967
    RRM2_RBM26_like; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:541616
    RRM1_RBM26; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26)
    cl02562
    Location:1176
    PWI; PWI domain
  44. XM_011535181.3XP_011533483.1  RNA-binding protein 26 isoform X3

    Conserved Domains (5) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    COG0419
    Location:734856
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd12258
    Location:898969
    RRM2_RBM26_like; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:546621
    RRM1_RBM26; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26)
    cl02562
    Location:1176
    PWI; PWI domain
  45. XM_011535179.3XP_011533481.1  RNA-binding protein 26 isoform X1

    Conserved Domains (5) summary
    smart00356
    Location:294314
    ZnF_C3H1; zinc finger
    COG0419
    Location:737859
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd12258
    Location:901972
    RRM2_RBM26_like; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:546621
    RRM1_RBM26; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26)
    cl02562
    Location:1176
    PWI; PWI domain
  46. XM_011535195.2XP_011533497.1  RNA-binding protein 26 isoform X46

    Conserved Domains (4) summary
    smart00356
    Location:626
    ZnF_C3H1; zinc finger
    cd12258
    Location:613684
    RRM2_RBM26_like; RNA recognition motif 2 of vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12516
    Location:258333
    RRM1_RBM26; RNA recognition motif 1 of vertebrate RNA-binding protein 26 (RBM26)
    pfam13864
    Location:465546
    Enkurin; Calmodulin-binding

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    78547111..78634324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018605.2: Suppressed sequence

    Description
    NM_018605.2: This RefSeq was permanently suppressed because it was generated in the wrong orientation.