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TSPYL2 TSPY like 2 [ Homo sapiens (human) ]

Gene ID: 64061, updated on 23-Nov-2021

Summary

Official Symbol
TSPYL2provided by HGNC
Official Full Name
TSPY like 2provided by HGNC
Primary source
HGNC:HGNC:24358
See related
Ensembl:ENSG00000184205 MIM:300564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
Summary
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
Expression
Broad expression in ovary (RPKM 45.2), testis (RPKM 42.8) and 24 other tissues See more
Orthologs
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Genomic context

See TSPYL2 in Genome Data Viewer
Location:
Xp11.22
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (53082367..53088540)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (53111549..53117722)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 156 member A Neighboring gene G protein-coupled receptor 173 Neighboring gene KANTR integral membrane protein Neighboring gene RNA, U7 small nuclear 37 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rDNA binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
testis-specific Y-encoded-like protein 2
Names
CASK-interacting nucleosome assembly protein
CTCL tumor antigen se20-4
CTCL-associated antigen se20-4
TSPY-like protein 2
cell division autoantigen 1
cutaneous T-cell lymphoma-associated antigen se20-4
cutaneous T-cell lymphoma-associated tumor antigen se20-4
differentially expressed nucleolar TGF-beta1 target
differentially-expressed nucleolar TGF-beta1 target protein
nuclear protein of 79 kDa
testis-specific protein Y encoded-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013267.1 RefSeqGene

    Range
    5008..11181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022117.4NP_071400.1  testis-specific Y-encoded-like protein 2

    See identical proteins and their annotated locations for NP_071400.1

    Status: REVIEWED

    Source sequence(s)
    BC024270, DA076199
    Consensus CDS
    CCDS14350.1
    UniProtKB/Swiss-Prot
    Q9H2G4
    Related
    ENSP00000364591.4, ENST00000375442.8
    Conserved Domains (2) summary
    pfam06957
    Location:543604
    COPI_C; Coatomer (COPI) alpha subunit C-terminus
    cl08298
    Location:227396
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    53082367..53088540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029727.2XP_016885216.1  testis-specific Y-encoded-like protein 2 isoform X2

  2. XM_017029726.2XP_016885215.1  testis-specific Y-encoded-like protein 2 isoform X1

    Conserved Domains (2) summary
    NF000535
    Location:486660
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    cl08298
    Location:227440
    NAP; Nucleosome assembly protein (NAP)
  3. XM_006724592.4XP_006724655.1  testis-specific Y-encoded-like protein 2 isoform X3

    Conserved Domains (2) summary
    pfam06957
    Location:543604
    COPI_C; Coatomer (COPI) alpha subunit C-terminus
    cl08298
    Location:227396
    NAP; Nucleosome assembly protein (NAP)

RNA

  1. XR_001755719.2 RNA Sequence

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