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Mre11a MRE11 homolog A, double strand break repair nuclease [ Rattus norvegicus (Norway rat) ]

Gene ID: 64046, updated on 19-Mar-2019

Summary

Official Symbol
Mre11aprovided by RGD
Official Full Name
MRE11 homolog A, double strand break repair nucleaseprovided by RGD
Primary source
RGD:69263
See related
Ensembl:ENSRNOG00000009506
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mre11
Summary
may play a role in regulation of cardiomyocyte proliferation [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 91.8), Spleen (RPKM 90.5) and 9 other tissues See more
Orthologs

Genomic context

See Mre11a in Genome Data Viewer
Location:
8q12
Exon count:
21
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (13304355..13350329)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (13244991..13290976)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 1700012B09 Neighboring gene ankyrin repeat domain 49 Neighboring gene G protein-coupled receptor 83 Neighboring gene uncharacterized LOC102549408

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
3'-5' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
3'-5'-exodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
5'-3' exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
5'-3' exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ATP-dependent DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to ATP-dependent DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
 
endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA endodeoxyribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
DNA strand resection involved in replication fork processing IEA
Inferred from Electronic Annotation
more info
 
DNA strand resection involved in replication fork processing ISO
Inferred from Sequence Orthology
more info
 
DNA strand resection involved in replication fork processing ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
chromosome organization ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
heart development IEP
Inferred from Expression Pattern
more info
PubMed 
intra-S DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intra-S DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
 
intra-S DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic G2 DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic G2 DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
 
mitotic G2 DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA endoreduplication IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA endoreduplication ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
 
sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
synapsis IEA
Inferred from Electronic Annotation
more info
 
synapsis ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomeric 3' overhang formation IEA
Inferred from Electronic Annotation
more info
 
telomeric 3' overhang formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Mre11 complex IEA
Inferred from Electronic Annotation
more info
 
Mre11 complex ISO
Inferred from Sequence Orthology
more info
 
PML body IEA
Inferred from Electronic Annotation
more info
 
PML body ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
replication fork IEA
Inferred from Electronic Annotation
more info
 
replication fork ISS
Inferred from Sequence or Structural Similarity
more info
 
site of double-strand break IEA
Inferred from Electronic Annotation
more info
 
site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
double-strand break repair protein MRE11; double-strand break repair protein MRE11A
Names
MRE11 homolog 1
MRE11 homolog, double strand break repair nuclease A
MRE11 meiotic recombination 11 homolog A
meiotic recombination 11 homolog 1
meiotic recombination 11 homolog A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022279.1NP_071615.1  double-strand break repair protein MRE11

    See identical proteins and their annotated locations for NP_071615.1

    Status: PROVISIONAL

    Source sequence(s)
    AF218574
    UniProtKB/Swiss-Prot
    Q9JIM0
    Related
    ENSRNOP00000012940.2, ENSRNOT00000012940.4
    Conserved Domains (3) summary
    TIGR00583
    Location:10402
    mre11; DNA repair protein (mre11)
    cd00840
    Location:14275
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    pfam04152
    Location:295462
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    13304355..13350329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242532.3XP_006242594.1  double-strand break repair protein MRE11A isoform X1

    See identical proteins and their annotated locations for XP_006242594.1

    UniProtKB/TrEMBL
    G3V781
    Conserved Domains (3) summary
    TIGR00583
    Location:10402
    mre11; DNA repair protein (mre11)
    cd00840
    Location:14275
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    pfam04152
    Location:295462
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  2. XM_006242533.2XP_006242595.1  double-strand break repair protein MRE11A isoform X1

    See identical proteins and their annotated locations for XP_006242595.1

    UniProtKB/TrEMBL
    G3V781
    Conserved Domains (3) summary
    TIGR00583
    Location:10402
    mre11; DNA repair protein (mre11)
    cd00840
    Location:14275
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    pfam04152
    Location:295462
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  3. XM_006242534.3XP_006242596.1  double-strand break repair protein MRE11A isoform X1

    See identical proteins and their annotated locations for XP_006242596.1

    UniProtKB/TrEMBL
    G3V781
    Conserved Domains (3) summary
    TIGR00583
    Location:10402
    mre11; DNA repair protein (mre11)
    cd00840
    Location:14275
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    pfam04152
    Location:295462
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    13102879..13146939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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