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Glrx glutaredoxin [ Rattus norvegicus (Norway rat) ]

Gene ID: 64045, updated on 21-Jul-2018

Summary

Official Symbol
Glrxprovided by RGD
Official Full Name
glutaredoxinprovided by RGD
Primary source
RGD:70951
See related
Ensembl:ENSRNOG00000012183 Vega:OTTRNOG00000001019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Grx; Glrx1
Summary
catalyzes the deglutathionylation of protein-SS-glutathione mixed disulfides [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 173.1), Liver (RPKM 153.8) and 9 other tissues See more
Orthologs

Genomic context

See Glrx in Genome Data Viewer
Location:
2q11
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (2606032..2615944)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (2604479..2614391)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene elongation factor for RNA polymerase II 2 Neighboring gene centromere protein R-like Neighboring gene glutathione S-transferase kappa 1-like Neighboring gene Rho-related BTB domain containing 3 Neighboring gene spermatogenesis associated 9 Neighboring gene Rieske (Fe-S) domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
glutathione disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione disulfide oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrogen peroxide-mediated programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovulation cycle process IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell adhesion molecule production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutaredoxin-1
Names
TTase-1
glutaredoxin (thioltransferase)
glutaredoxin 1 (thioltransferase)
thioltransferase-1
NP_071614.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022278.1NP_071614.1  glutaredoxin-1

    See identical proteins and their annotated locations for NP_071614.1

    Status: PROVISIONAL

    Source sequence(s)
    AF167981
    UniProtKB/Swiss-Prot
    Q9ESH6
    Related
    ENSRNOP00000016372.2, OTTRNOP00000000874, ENSRNOT00000016372.5, OTTRNOT00000001555
    Conserved Domains (1) summary
    TIGR02180
    Location:1599
    GRX_euk; Glutaredoxin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    2606032..2615944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    1812028..1821780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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