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Casp8 caspase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64044, updated on 12-Nov-2024

Summary

Official Symbol
Casp8provided by RGD
Official Full Name
caspase 8provided by RGD
Primary source
RGD:620945
See related
EnsemblRapid:ENSRNOG00000012331 AllianceGenome:RGD:620945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CASP-8
Summary
Enables cysteine-type endopeptidase activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including positive regulation of neuron apoptotic process; response to estradiol; and response to lipopolysaccharide. Located in cell body. Part of CD95 death-inducing signaling complex. Used to study pre-malignant neoplasm. Biomarker of several diseases, including heart disease (multiple); kidney disease (multiple); lung disease (multiple); sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and lung cancer. Orthologous to human CASP8 (caspase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 214.2), Spleen (RPKM 146.4) and 8 other tissues See more
Orthologs
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Genomic context

See Casp8 in Genome Data Viewer
Location:
9q31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67747109..67806699)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60263863..60312542)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65614142..65662624)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene uncharacterized LOC100909946 Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene uncharacterized LOC120094796 Neighboring gene trafficking kinesin protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
enables death effector domain binding ISO
Inferred from Sequence Orthology
more info
 
enables death receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in TRAIL-activated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within neural tube formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis involved in protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptotic inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to auditory stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cobalt ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in self proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in self proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CD95 death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CD95 death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
part_of Noc1p-Noc2p complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ripoptosome ISO
Inferred from Sequence Orthology
more info
 
part_of ripoptosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
caspase-8
NP_071613.1
XP_006245077.1
XP_038940092.1
XP_038940093.1
XP_038940094.1
XP_063123742.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022277.2NP_071613.1  caspase-8

    See identical proteins and their annotated locations for NP_071613.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q9JHX4
    Related
    ENSRNOP00000103046.1, ENSRNOT00000140357.1
    Conserved Domains (3) summary
    cd00032
    Location:227480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98179
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    67747109..67806699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267672.1XP_063123742.1  caspase-8 isoform X1

  2. XM_006245015.5XP_006245077.1  caspase-8 isoform X1

    See identical proteins and their annotated locations for XP_006245077.1

    UniProtKB/Swiss-Prot
    Q9JHX4
    Conserved Domains (3) summary
    cd00032
    Location:227480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98179
    DD; Death Domain Superfamily of protein-protein interaction domains
  3. XM_039084164.2XP_038940092.1  caspase-8 isoform X1

    UniProtKB/Swiss-Prot
    Q9JHX4
    Related
    ENSRNOP00000016613.3, ENSRNOT00000016613.6
    Conserved Domains (3) summary
    cd00032
    Location:227480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98179
    DD; Death Domain Superfamily of protein-protein interaction domains
  4. XM_039084166.2XP_038940094.1  caspase-8 isoform X2

    Conserved Domains (1) summary
    cd00032
    Location:21274
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  5. XM_039084165.1XP_038940093.1  caspase-8 isoform X2

    Conserved Domains (1) summary
    cd00032
    Location:21274
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...