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Casp8 caspase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64044, updated on 22-Nov-2020

Summary

Official Symbol
Casp8provided by RGD
Official Full Name
caspase 8provided by RGD
Primary source
RGD:620945
See related
Ensembl:ENSRNOG00000012331
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CASP-8
Summary
member of the cysteine-aspartic acid protease (caspase) familythat mediates the terminal stage of apoptosis; involved in apoptosis induced by Fas and other stimuli [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 214.2), Spleen (RPKM 146.4) and 8 other tissues See more
Orthologs

Genomic context

See Casp8 in Genome Data Viewer
Location:
9q31
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65614142..65662624)
106 current Rn_Celera (GCF_000002265.2) 9 AC_000077.1 (57705001..57753027)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (65420843..65469468)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909946 Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene uncharacterized LOC102550737 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene trafficking kinesin protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
death effector domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
death effector domain binding ISO
Inferred from Sequence Orthology
more info
 
death receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
TRAIL-activated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
macrophage differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
neural tube formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
protein processing ISO
Inferred from Sequence Orthology
more info
 
protein processing ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
proteolysis involved in cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
pyroptosis ISO
Inferred from Sequence Orthology
more info
 
pyroptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
response to auditory stimulus ISO
Inferred from Sequence Orthology
more info
 
response to cobalt ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to cold IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
self proteolysis ISO
Inferred from Sequence Orthology
more info
 
self proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
CD95 death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
CD95 death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
Noc1p-Noc2p complex ISO
Inferred from Sequence Orthology
more info
 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
ripoptosome ISO
Inferred from Sequence Orthology
more info
 
ripoptosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
caspase-8
NP_071613.1
XP_006245077.1
XP_008765357.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022277.1NP_071613.1  caspase-8

    See identical proteins and their annotated locations for NP_071613.1

    Status: PROVISIONAL

    Source sequence(s)
    AF279308
    UniProtKB/Swiss-Prot
    Q9JHX4
    Related
    ENSRNOP00000016613.2, ENSRNOT00000016613.4
    Conserved Domains (3) summary
    cd00032
    Location:227480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98179
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

    Range
    65614142..65662624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245015.3XP_006245077.1  caspase-8 isoform X2

    See identical proteins and their annotated locations for XP_006245077.1

    UniProtKB/Swiss-Prot
    Q9JHX4
    Conserved Domains (3) summary
    cd00032
    Location:227480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98179
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. XM_008767135.2XP_008765357.1  caspase-8 isoform X1

    See identical proteins and their annotated locations for XP_008765357.1

    Conserved Domains (3) summary
    cd00032
    Location:249502
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:25106
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:120201
    DD; Death Domain Superfamily of protein-protein interaction domains

Alternate Rn_Celera

Genomic

  1. AC_000077.1 Alternate Rn_Celera

    Range
    57705001..57753027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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