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Gcnt1 glucosaminyl (N-acetyl) transferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64043, updated on 26-Sep-2025
Official Symbol
Gcnt1provided by RGD
Official Full Name
glucosaminyl (N-acetyl) transferase 1provided by RGD
Primary source
RGD:621370
See related
Ensembl:ENSRNOG00000062686 AllianceGenome:RGD:621370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
core 2 GlcNAc-T
Summary
Enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity. Involved in response to insulin. Located in extracellular space. Orthologous to human GCNT1 (glucosaminyl (N-acetyl) transferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Heart (RPKM 145.4), Spleen (RPKM 83.1) and 9 other tissues See more
Orthologs
human mouse all
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See Gcnt1 in Genome Data Viewer
Location:
1q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (224145104..224182496, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (214718344..214755735, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (236547729..236585037)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene forkhead box B2 Neighboring gene prune homolog 2 with BCH domain Neighboring gene uncharacterized LOC134483972 Neighboring gene acyl-protein thioesterase 1-like Neighboring gene riboflavin kinase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. beta1,6 N-acetylglucosaminyltransferase (core 2 GlcNAc-T) expression in normal rat tissues and different cell lines: evidence for complex mechanisms of regulation. VanderElst IE, et al. Glycobiology, 1998 Jul. PMID 9621114
  2. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. Nishio Y, et al. J Clin Invest, 1995 Oct. PMID 7560067, Free PMC Article
  3. Golgi phosphoprotein 3 determines cell binding properties under dynamic flow by controlling Golgi localization of core 2 N-acetylglucosaminyltransferase 1. Ali MF, et al. J Biol Chem, 2012 Nov 16. PMID 23027862, Free PMC Article
  4. Glycosyltransferase function in core 2-type protein O glycosylation. Stone EL, et al. Mol Cell Biol, 2009 Jul. PMID 19349303, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion molecule production ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Names
beta1,6 N-acetylglucosaminyltransferase
enzymatic glycosylation-regulating
glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
glucosaminyl transferase 1, core 2
NP_071612.1
XP_006231209.1
XP_006231212.1
XP_038945223.1
XP_038945229.1
XP_063128739.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001443558.1 → NP_001430487.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  2. NM_001443559.1 → NP_001430488.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  3. NM_022276.3 → NP_071612.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_071612.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZR94, Q64165
    Conserved Domains (1) summary
    pfam02485
    Location:123 → 391
    Branch; Core-2/I-Branching enzyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    224145104..224182496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089301.2 → XP_038945229.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZR94, Q64165
    Conserved Domains (1) summary
    pfam02485
    Location:123 → 391
    Branch; Core-2/I-Branching enzyme

  2. XM_006231147.4 → XP_006231209.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZR94, Q64165
    Related
    ENSRNOP00000080877.1, ENSRNOT00000119573.2
    Conserved Domains (1) summary
    pfam02485
    Location:123 → 391
    Branch; Core-2/I-Branching enzyme

  3. XM_039089295.2 → XP_038945223.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZR94, Q64165
    Conserved Domains (1) summary
    pfam02485
    Location:123 → 391
    Branch; Core-2/I-Branching enzyme

  4. XM_063272669.1 → XP_063128739.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZR94, Q64165
    Related
    ENSRNOP00000095789.1, ENSRNOT00000118591.2

  5. XM_006231150.4 → XP_006231212.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006231212.1

    UniProtKB/TrEMBL
    A0A8I5ZR94, Q64165
    Related
    ENSRNOP00000083711.1, ENSRNOT00000108297.2
    Conserved Domains (1) summary
    pfam02485
    Location:123 → 391
    Branch; Core-2/I-Branching enzyme
Nucleotide Protein Strain
Heading Accession and Version

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