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Nmur2 neuromedin U receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64042, updated on 4-Jun-2020

Summary

Official Symbol
Nmur2provided by RGD
Official Full Name
neuromedin U receptor 2provided by RGD
Primary source
RGD:621155
See related
Ensembl:ENSRNOG00000014081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FM-4; Nmu2r
Summary
receptor for the Nmu neuropeptide involved in the central control of feeding [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 154.6) See more
Orthologs

Genomic context

See Nmur2 in Genome Data Viewer
Location:
10q22
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (41392663..41408518, complement)
106 current Rn_Celera (GCF_000002265.2) 10 AC_000078.1 (39485666..39501503, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (41219613..41235468, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene protein UXT pseudogene Neighboring gene glycine receptor, alpha 1 Neighboring gene similar to High mobility group protein 1 (HMG-1) Neighboring gene uncharacterized LOC102552546 Neighboring gene uncharacterized LOC102552619 Neighboring gene uncharacterized LOC102552882 Neighboring gene uncharacterized LOC102552810

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GTP binding ISO
Inferred from Sequence Orthology
more info
 
intracellular calcium activated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
neuromedin U binding ISO
Inferred from Sequence Orthology
more info
 
neuromedin U receptor activity ISO
Inferred from Sequence Orthology
more info
 
neuropeptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of phospholipase A2 activity by calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
central nervous system development ISO
Inferred from Sequence Orthology
more info
 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
grooming behavior ISO
Inferred from Sequence Orthology
more info
 
inositol phosphate-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
reduction of food intake in response to dietary excess ISO
Inferred from Sequence Orthology
more info
 
regulation of sensory perception of pain IDA
Inferred from Direct Assay
more info
PubMed 
response to pain ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuromedin-U receptor 2
Names
G-protein coupled receptor TGR-1
G-protein-coupled receptor FM-4
NMU-R2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022275.3NP_071611.3  neuromedin-U receptor 2

    See identical proteins and their annotated locations for NP_071611.3

    Status: VALIDATED

    Source sequence(s)
    AABR07029623, AB041229, AF242875, BM384513, CB556410
    UniProtKB/Swiss-Prot
    Q9ESQ4
    Related
    ENSRNOP00000018967.1, ENSRNOT00000018967.3
    Conserved Domains (2) summary
    pfam00001
    Location:54319
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:48333
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    41392663..41408518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    39485666..39501503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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