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Aldh9a1 aldehyde dehydrogenase 9 family, member A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64040, updated on 8-Dec-2022

Summary

Symbol
Aldh9a1provided by RGD
Full Name
aldehyde dehydrogenase 9 family, member A1provided by RGD
Primary source
RGD:68409
See related
Ensembl:ENSRNOG00000004027 AllianceGenome:RGD:68409
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmaba-dh
Summary
Enables several functions, including NAD binding activity; identical protein binding activity; and oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Involved in kidney development and liver development. Located in cytosol. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1093.3), Kidney (RPKM 762.2) and 9 other tissues See more
Orthologs
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Genomic context

See Aldh9a1 in Genome Data Viewer
Location:
13q24
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (79505738..79522539)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (85580828..85597497)

Chromosome 13 - NC_051348.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352567 Neighboring gene transmembrane and coiled-coil domains 1 Neighboring gene H/ACA ribonucleoprotein complex subunit 3 pseudogene Neighboring gene microsomal glutathione S-transferase 3 Neighboring gene osteoclast stimulating factor 1, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-pyrroline dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aldehyde dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables amine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables aminobutyraldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aminobutyraldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aminobutyraldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in carnitine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carnitine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within carnitine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular aldehyde metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular aldehyde metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in liver development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neurotransmitter biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
4-trimethylaminobutyraldehyde dehydrogenase
Names
4-trimethylaminobutyraldehyde dehydrogenase-like
TMABADH
aldehyde dehydrogenase 9A1
aldehyde dehydrogenase family 9 member A1
aldehyde dehydrogenase family 9, subfamily A1
gamma-aminobutyraldehyde dehydrogenase
gamma-trimethylaminobutyraldehyde dehydrogenase
NP_071609.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022273.2NP_071609.2  4-trimethylaminobutyraldehyde dehydrogenase

    See identical proteins and their annotated locations for NP_071609.2

    Status: PROVISIONAL

    Source sequence(s)
    BC074019
    UniProtKB/Swiss-Prot
    Q9JLJ3
    UniProtKB/TrEMBL
    A0A0G2JSI1, A0A8I6AQJ5
    Related
    ENSRNOP00000005611.6, ENSRNOT00000005611.6
    Conserved Domains (1) summary
    cd07090
    Location:31488
    ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051348.1 Reference mRatBN7.2 Primary Assembly

    Range
    79505738..79522539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)