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Slc22a4 solute carrier family 22 member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64037, updated on 25-Jan-2022

Summary

Official Symbol
Slc22a4provided by RGD
Official Full Name
solute carrier family 22 member 4provided by RGD
Primary source
RGD:621149
See related
Ensembl:ENSRNOG00000046195 AllianceGenome:RGD:621149
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Octn1
Summary
Enables quaternary ammonium group transmembrane transporter activity. Involved in quaternary ammonium group transport. Predicted to be located in apical plasma membrane and mitochondrion. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human SLC22A4 (solute carrier family 22 member 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Spleen (RPKM 105.6), Kidney (RPKM 96.3) and 5 other tissues See more
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Genomic context

See Slc22a4 in Genome Data Viewer
Location:
10q22
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (38133333..38179932, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39334972..39373508, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 4-like Neighboring gene up-regulator of carnitine transporter, OCTN2 Neighboring gene PDZ and LIM domain 4 Neighboring gene prolyl 4-hydroxylase subunit alpha 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables carnitine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables carnitine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables cation:cation antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables cation:cation antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables organic cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables quaternary ammonium group transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables quaternary ammonium group transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables quaternary ammonium group transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables quaternary ammonium group transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in amino acid import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within carnitine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in carnitine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within carnitine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in quaternary ammonium group transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in quaternary ammonium group transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in quaternary ammonium group transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within quaternary ammonium group transport ISO
Inferred from Sequence Orthology
more info
 
involved_in quaternary ammonium group transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
 
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
solute carrier family 22 member 4
Names
organic cation transporter OCTN1
organic cation/carnitine transporter 1
solute carrier family 22 (organic cation transporter), member 4
solute carrier family 22 (organic cation/zwitterion transporter), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022270.2NP_071606.1  solute carrier family 22 member 4

    See identical proteins and their annotated locations for NP_071606.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000219
    UniProtKB/Swiss-Prot
    Q9R141
    Related
    ENSRNOP00000055693.5, ENSRNOT00000058907.5
    Conserved Domains (1) summary
    TIGR00898
    Location:12519
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    38133333..38179932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086772.1XP_038942700.1  solute carrier family 22 member 4 isoform X1

    Conserved Domains (1) summary
    TIGR00898
    Location:12458
    2A0119; cation transport protein
  2. XM_039086773.1XP_038942701.1  solute carrier family 22 member 4 isoform X2

    Conserved Domains (1) summary
    TIGR00898
    Location:12427
    2A0119; cation transport protein
  3. XM_039086774.1XP_038942702.1  solute carrier family 22 member 4 isoform X3

    Conserved Domains (1) summary
    cl28910
    Location:13402
    MFS; Major Facilitator Superfamily
  4. XM_039086777.1XP_038942705.1  solute carrier family 22 member 4 isoform X4

    Conserved Domains (1) summary
    cl28910
    Location:1334
    MFS; Major Facilitator Superfamily
  5. XM_039086775.1XP_038942703.1  solute carrier family 22 member 4 isoform X4

    Conserved Domains (1) summary
    cl28910
    Location:1334
    MFS; Major Facilitator Superfamily
  6. XM_039086776.1XP_038942704.1  solute carrier family 22 member 4 isoform X4

    Conserved Domains (1) summary
    cl28910
    Location:1334
    MFS; Major Facilitator Superfamily
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