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Kit KIT proto-oncogene receptor tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 64030, updated on 10-Jun-2018
Official Symbol
Kitprovided by RGD
Official Full Name
KIT proto-oncogene receptor tyrosine kinaseprovided by RGD
Primary source
RGD:620568
See related
Ensembl:ENSRNOG00000002227 Vega:OTTRNOG00000001677
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
transmembrane receptor; deletion mutation is associated with anemia and deficiency in mast cells and melanocytes in the Ws mutant allele of rats [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 350.8), Brain (RPKM 125.4) and 9 other tissues See more
Orthologs
See Kit in Genome Data Viewer
Location:
14p11
Exon count:
21
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (35072131..35149638, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (34901860..34979384, complement)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene kinase insert domain receptor Neighboring gene uncharacterized LOC102553643 Neighboring gene similar to CG1249-PA Neighboring gene uncharacterized LOC102553856

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine binding IEA
Inferred from Electronic Annotation
more info
 
cytokine binding ISO
Inferred from Sequence Orthology
more info
 
growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
stem cell factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
stem cell factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Fc receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Kit signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to thyroid hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
dendritic cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
dendritic cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
detection of mechanical stimulus involved in sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
detection of mechanical stimulus involved in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
developmental pigmentation ISO
Inferred from Sequence Orthology
more info
 
digestive tract development IEA
Inferred from Electronic Annotation
more info
 
digestive tract development ISO
Inferred from Sequence Orthology
more info
 
ectopic germ cell programmed cell death IEA
Inferred from Electronic Annotation
more info
 
ectopic germ cell programmed cell death ISO
Inferred from Sequence Orthology
more info
 
embryonic hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
erythropoietin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
erythropoietin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycosphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycosphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
hematopoietic stem cell migration IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell migration ISO
Inferred from Sequence Orthology
more info
 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
immature B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
immature B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
lymphoid progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lymphoid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
mast cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
mast cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
mast cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
mast cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mast cell differentiation ISO
Inferred from Sequence Orthology
more info
 
megakaryocyte development IEA
Inferred from Electronic Annotation
more info
 
megakaryocyte development ISO
Inferred from Sequence Orthology
more info
 
melanocyte adhesion IEA
Inferred from Electronic Annotation
more info
 
melanocyte adhesion ISO
Inferred from Sequence Orthology
more info
 
melanocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
melanocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
melanocyte migration IEA
Inferred from Electronic Annotation
more info
 
melanocyte migration ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myeloid leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
myeloid progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
myeloid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of programmed cell death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
pigmentation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of colon smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pseudopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pyloric antrum smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of small intestine smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of bile acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
regulation of developmental pigmentation IEA
Inferred from Electronic Annotation
more info
 
regulation of developmental pigmentation ISO
Inferred from Sequence Orthology
more info
 
response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to radiation ISO
Inferred from Sequence Orthology
more info
 
somatic stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
spermatid development ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
tongue development IEP
Inferred from Expression Pattern
more info
PubMed 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mast cell granule IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
mast/stem cell growth factor receptor Kit
Names
Kit oncogene
c-kit receptor tyrosine kinase
protein kinase
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
NP_071600.1
XP_006250971.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022264.1NP_071600.1  mast/stem cell growth factor receptor Kit precursor

    See identical proteins and their annotated locations for NP_071600.1

    Status: PROVISIONAL

    Source sequence(s)
    D12524
    UniProtKB/TrEMBL
    Q63116
    Related
    ENSRNOP00000003050.1, OTTRNOP00000001539, ENSRNOT00000003050.3, OTTRNOT00000002673
    Conserved Domains (6) summary
    cd05860
    Location:313413
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220309
    IG_like; Immunoglobulin like
    pfam00047
    Location:216307
    ig; Immunoglobulin domain
    pfam07714
    Location:591925
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:428503
    Ig; Immunoglobulin domain
    cl21453
    Location:555929
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    35072131..35149638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250909.3XP_006250971.1  mast/stem cell growth factor receptor Kit isoform X1

    See identical proteins and their annotated locations for XP_006250971.1

    UniProtKB/TrEMBL
    A0A0G2JTL4
    Related
    ENSRNOP00000068756.1, ENSRNOT00000090654.1
    Conserved Domains (6) summary
    cd05860
    Location:313413
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220309
    IG_like; Immunoglobulin like
    pfam00047
    Location:216307
    ig; Immunoglobulin domain
    pfam07714
    Location:587921
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:428503
    Ig; Immunoglobulin domain
    cl21453
    Location:551925
    PKc_like; Protein Kinases, catalytic domain

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    31837543..31913518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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