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Kit KIT proto-oncogene receptor tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 64030, updated on 10-May-2022

Summary

Official Symbol
Kitprovided by RGD
Official Full Name
KIT proto-oncogene receptor tyrosine kinaseprovided by RGD
Primary source
RGD:620568
See related
Ensembl:ENSRNOG00000002227 AllianceGenome:RGD:620568
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein tyrosine kinase activity. Involved in several processes, including gamete generation; positive regulation of gastro-intestinal system smooth muscle contraction; and protein phosphorylation. Located in acrosomal vesicle; cytoplasmic side of plasma membrane; and external side of plasma membrane. Used to study aplastic anemia and male infertility. Biomarker of acute pancreatitis and gastroschisis. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 350.8), Brain (RPKM 125.4) and 9 other tissues See more
Orthologs
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Genomic context

See Kit in Genome Data Viewer
Location:
14p11
Exon count:
21
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (32547459..32624694, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (35072131..35149638, complement)

Chromosome 14 - NC_051349.1Genomic Context describing neighboring genes Neighboring gene kinase insert domain receptor Neighboring gene uncharacterized LOC120096529 Neighboring gene U6 spliceosomal RNA Neighboring gene similar to CG1249-PA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables stem cell factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Fc receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Kit signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Kit signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within developmental pigmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in digestive tract development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ectopic germ cell programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in erythropoietin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glycosphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hematopoietic progenitor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in immature B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lymphoid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in mast cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in megakaryocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in melanocyte adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in melanocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in melanocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within myeloid leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pigmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in pigmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of colon smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mast cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pseudopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of pyloric antrum smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of small intestine smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bile acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in somatic stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in tongue development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mast/stem cell growth factor receptor Kit
Names
Kit oncogene
c-kit receptor tyrosine kinase
protein kinase
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
NP_071600.1
XP_006250971.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022264.2NP_071600.1  mast/stem cell growth factor receptor Kit precursor

    See identical proteins and their annotated locations for NP_071600.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000252
    UniProtKB/TrEMBL
    Q63116
    Related
    ENSRNOP00000003050.1, ENSRNOT00000003050.4
    Conserved Domains (6) summary
    cd05860
    Location:313413
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220309
    IG_like; Immunoglobulin like
    pfam00047
    Location:216307
    ig; Immunoglobulin domain
    pfam07714
    Location:591925
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:428503
    Ig; Immunoglobulin domain
    cl21453
    Location:555929
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051349.1 Reference mRatBN7.2 Primary Assembly

    Range
    32547459..32624694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250909.4XP_006250971.1  mast/stem cell growth factor receptor Kit isoform X1

    See identical proteins and their annotated locations for XP_006250971.1

    UniProtKB/TrEMBL
    A0A0G2JTL4
    Conserved Domains (6) summary
    cd05860
    Location:313413
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220309
    IG_like; Immunoglobulin like
    pfam00047
    Location:216307
    ig; Immunoglobulin domain
    pfam07714
    Location:587921
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:428503
    Ig; Immunoglobulin domain
    cl21453
    Location:551925
    PKc_like; Protein Kinases, catalytic domain