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Aqp9 aquaporin 9 [ Mus musculus (house mouse) ]

Gene ID: 64008, updated on 21-Apr-2024

Summary

Official Symbol
Aqp9provided by MGI
Official Full Name
aquaporin 9provided by MGI
Primary source
MGI:MGI:1891066
See related
Ensembl:ENSMUSG00000032204 AllianceGenome:MGI:1891066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AQP-9; 1700020I22Rik
Summary
This gene encodes a member of the aquaglyceroporin subfamily of aquaporins. This protein transports water, glycerol, urea, purines and pyrimidines and plays a role in glycerol metabolism and osteoclast differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Biased expression in liver adult (RPKM 30.0), liver E18 (RPKM 8.4) and 4 other tissues See more
Orthologs
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Genomic context

Location:
9 D; 9 39.85 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (71017941..71075170, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (71110659..71167849, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46119 Neighboring gene STARR-positive B cell enhancer ABC_E8298 Neighboring gene predicted gene, 46120 Neighboring gene STARR-seq mESC enhancer starr_24565 Neighboring gene predicted gene, 32714 Neighboring gene STARR-seq mESC enhancer starr_24566 Neighboring gene predicted gene, 32511 Neighboring gene STARR-seq mESC enhancer starr_24567 Neighboring gene STARR-seq mESC enhancer starr_24568 Neighboring gene predicted gene 3458

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
 
enables glycerol channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycerol channel activity ISO
Inferred from Sequence Orthology
more info
 
enables polyol transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables purine nucleobase transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables pyrimidine nucleobase transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables urea channel activity ISO
Inferred from Sequence Orthology
more info
 
enables urea transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables urea transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables water channel activity ISO
Inferred from Sequence Orthology
more info
 
enables water channel activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in amine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in canalicular bile acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in glycerol transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycerol transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in polyol transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in purine nucleobase transport ISO
Inferred from Sequence Orthology
more info
 
involved_in pyrimidine nucleobase transport ISO
Inferred from Sequence Orthology
more info
 
involved_in response to pain ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in urea transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in water transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in water transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within water transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
aquaporin-9
Names
aquaglyceroporin-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271843.1NP_001258772.1  aquaporin-9 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC098716
    Consensus CDS
    CCDS72270.1
    UniProtKB/TrEMBL
    D3YYD6
    Related
    ENSMUSP00000050127.6, ENSMUST00000060917.12
    Conserved Domains (1) summary
    cl00200
    Location:61292
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  2. NM_022026.3NP_071309.1  aquaporin-9 isoform 1

    See identical proteins and their annotated locations for NP_071309.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI789806, AK050042
    Consensus CDS
    CCDS23325.1
    UniProtKB/Swiss-Prot
    Q9JJJ3
    UniProtKB/TrEMBL
    Q4FK77
    Related
    ENSMUSP00000074063.3, ENSMUST00000074465.9
    Conserved Domains (1) summary
    cl00200
    Location:24266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RNA

  1. NR_073483.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC098716
    Related
    ENSMUST00000144618.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    71017941..71075170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242783.3XP_011241085.1  aquaporin-9 isoform X1

    See identical proteins and their annotated locations for XP_011241085.1

    UniProtKB/Swiss-Prot
    Q9JJJ3
    UniProtKB/TrEMBL
    Q4FK77
    Conserved Domains (1) summary
    cl00200
    Location:24266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  2. XM_006511331.3XP_006511394.1  aquaporin-9 isoform X1

    See identical proteins and their annotated locations for XP_006511394.1

    UniProtKB/Swiss-Prot
    Q9JJJ3
    UniProtKB/TrEMBL
    Q4FK77
    Conserved Domains (1) summary
    cl00200
    Location:24266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  3. XM_036155169.1XP_036011062.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    Q9JJJ3
    UniProtKB/TrEMBL
    Q4FK77
    Related
    ENSMUSP00000109200.2, ENSMUST00000113570.8
    Conserved Domains (1) summary
    cl00200
    Location:24266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  4. XM_011242782.4XP_011241084.1  aquaporin-9 isoform X1

    See identical proteins and their annotated locations for XP_011241084.1

    UniProtKB/Swiss-Prot
    Q9JJJ3
    UniProtKB/TrEMBL
    Q4FK77
    Conserved Domains (1) summary
    cl00200
    Location:24266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  5. XM_006511332.5XP_006511395.1  aquaporin-9 isoform X1

    See identical proteins and their annotated locations for XP_006511395.1

    UniProtKB/Swiss-Prot
    Q9JJJ3
    UniProtKB/TrEMBL
    Q4FK77
    Conserved Domains (1) summary
    cl00200
    Location:24266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...