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SECTM1 secreted and transmembrane 1 [ Homo sapiens (human) ]

Gene ID: 6398, updated on 24-Nov-2020

Summary

Official Symbol
SECTM1provided by HGNC
Official Full Name
secreted and transmembrane 1provided by HGNC
Primary source
HGNC:HGNC:10707
See related
Ensembl:ENSG00000141574 MIM:602602
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K12; SECTM
Summary
This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 29.2), duodenum (RPKM 20.3) and 17 other tissues See more
Orthologs

Genomic context

See SECTM1 in Genome Data Viewer
Location:
17q25.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (82321024..82333951, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80278900..80291921, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985059 Neighboring gene CD7 molecule Neighboring gene testis expressed 19 Neighboring gene urotensin 2 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
immune response IEA
Inferred from Electronic Annotation
more info
 
mesoderm development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
secreted and transmembrane protein 1
Names
type 1a transmembrane protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003004.3NP_002995.1  secreted and transmembrane protein 1 precursor

    See identical proteins and their annotated locations for NP_002995.1

    Status: REVIEWED

    Source sequence(s)
    AC132872, BI861812, DA589733, U77643
    Consensus CDS
    CCDS11808.1
    UniProtKB/Swiss-Prot
    Q8WVN6
    Related
    ENSP00000269389.3, ENST00000269389.8
    Conserved Domains (1) summary
    pfam15492
    Location:6152
    Nbas_N; Neuroblastoma-amplified sequence, N terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    82321024..82333951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256392.3XP_005256449.1  secreted and transmembrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005256449.1

    UniProtKB/Swiss-Prot
    Q8WVN6
    Conserved Domains (1) summary
    pfam15492
    Location:6152
    Nbas_N; Neuroblastoma-amplified sequence, N terminal
  2. XM_011523588.2XP_011521890.1  secreted and transmembrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521890.1

    UniProtKB/Swiss-Prot
    Q8WVN6
    Conserved Domains (1) summary
    pfam15492
    Location:6152
    Nbas_N; Neuroblastoma-amplified sequence, N terminal
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