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PRDM14 PR/SET domain 14 [ Homo sapiens (human) ]

Gene ID: 63978, updated on 23-Nov-2021

Summary

Official Symbol
PRDM14provided by HGNC
Official Full Name
PR/SET domain 14provided by HGNC
Primary source
HGNC:HGNC:14001
See related
Ensembl:ENSG00000147596 MIM:611781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFM11
Summary
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See PRDM14 in Genome Data Viewer
Location:
8q13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (70051613..70071252, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (70963886..70983487, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene syndecan binding protein pseudogene 2 Neighboring gene SUMO2 pseudogene 20 Neighboring gene RNA, U1 small nuclear 101, pseudogene Neighboring gene H2A.Z histone pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of PR domain containing 14 (PRDM14) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC59730

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryo implantation IEA
Inferred from Electronic Annotation
more info
 
involved_in fertilization IEA
Inferred from Electronic Annotation
more info
 
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in germ-line stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3-R26 methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
involved_in inactivation of paternal X chromosome IEA
Inferred from Electronic Annotation
more info
 
involved_in inner cell mass cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PR domain zinc finger protein 14
Names
PR domain 14
PR domain-containing 14
PR domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024504.4NP_078780.1  PR domain zinc finger protein 14

    See identical proteins and their annotated locations for NP_078780.1

    Status: REVIEWED

    Source sequence(s)
    AF319458, CX166395, CX788380
    Consensus CDS
    CCDS6206.1
    UniProtKB/Swiss-Prot
    Q9GZV8
    Related
    ENSP00000276594.2, ENST00000276594.3
    Conserved Domains (4) summary
    smart00317
    Location:266371
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5048
    Location:460568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:463483
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:548565
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    70051613..70071252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517572.2XP_011515874.1  PR domain zinc finger protein 14 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:205313
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:208228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:293310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:206228
    zf-C2H2; Zinc finger, C2H2 type
    pfam00856
    Location:11112
    SET; SET domain
    pfam13465
    Location:249273
    zf-H2C2_2; Zinc-finger double domain
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