Format

Send to:

Choose Destination

NEUROD6 neuronal differentiation 6 [ Homo sapiens (human) ]

Gene ID: 63974, updated on 23-Nov-2021

Summary

Official Symbol
NEUROD6provided by HGNC
Official Full Name
neuronal differentiation 6provided by HGNC
Primary source
HGNC:HGNC:13804
See related
Ensembl:ENSG00000164600 MIM:611513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nex1; Atoh2; MATH2; NEX1M; Math-2; bHLHa2
Summary
This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012]
Expression
Restricted expression toward brain (RPKM 7.3) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NEUROD6 in Genome Data Viewer
Location:
7p14.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (31337465..31340726, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (31377079..31380340, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986781 Neighboring gene uncharacterized LOC107986782 Neighboring gene VISTA enhancer hs297 Neighboring gene uncharacterized LOC105375224

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ56829

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in dentate gyrus development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neurogenic differentiation factor 6
Names
brain my051 protein
class A basic helix-loop-helix protein 2
protein atonal homolog 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022728.4NP_073565.2  neurogenic differentiation factor 6

    See identical proteins and their annotated locations for NP_073565.2

    Status: REVIEWED

    Source sequence(s)
    AF248954
    Consensus CDS
    CCDS5434.1
    UniProtKB/Swiss-Prot
    Q96NK8
    UniProtKB/TrEMBL
    A0A090N7T3
    Related
    ENSP00000297142.3, ENST00000297142.4
    Conserved Domains (2) summary
    cd19722
    Location:82151
    bHLH_TS_NeuroD6_ATOH2; basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) and similar proteins
    pfam12533
    Location:153272
    Neuro_bHLH; Neuronal helix-loop-helix transcription factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    31337465..31340726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center