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NEUROD6 neuronal differentiation 6 [ Homo sapiens (human) ]

Gene ID: 63974, updated on 5-Mar-2024

Summary

Official Symbol
NEUROD6provided by HGNC
Official Full Name
neuronal differentiation 6provided by HGNC
Primary source
HGNC:HGNC:13804
See related
Ensembl:ENSG00000164600 MIM:611513; AllianceGenome:HGNC:13804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nex1; Atoh2; MATH2; NEX1M; Math-2; bHLHa2
Summary
This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012]
Expression
Restricted expression toward brain (RPKM 7.3) See more
Orthologs
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Genomic context

See NEUROD6 in Genome Data Viewer
Location:
7p14.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (31337465..31340726, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (31475149..31478410, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (31377079..31380340, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18076 Neighboring gene uncharacterized LOC107986781 Neighboring gene uncharacterized LOC107986782 Neighboring gene VISTA enhancer hs297 Neighboring gene NANOG hESC enhancer GRCh37_chr7:31411185-31411804 Neighboring gene uncharacterized LOC105375224 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:31505615-31506326 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:31506327-31507037 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:31517206-31518405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25823 Neighboring gene ITPR interacting domain containing 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:31690801-31691359 Neighboring gene phosphodiesterase 1C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ56829

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dentate gyrus development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
neurogenic differentiation factor 6
Names
brain my051 protein
class A basic helix-loop-helix protein 2
protein atonal homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022728.4NP_073565.2  neurogenic differentiation factor 6

    See identical proteins and their annotated locations for NP_073565.2

    Status: REVIEWED

    Source sequence(s)
    AF248954
    Consensus CDS
    CCDS5434.1
    UniProtKB/Swiss-Prot
    Q548T9, Q96NK8, Q9H3H6
    UniProtKB/TrEMBL
    A0A090N7T3, B3KNX6, Q7Z4W9, Q8IYR9
    Related
    ENSP00000297142.3, ENST00000297142.4
    Conserved Domains (2) summary
    cd19722
    Location:82151
    bHLH_TS_NeuroD6_ATOH2; basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) and similar proteins
    pfam12533
    Location:153272
    Neuro_bHLH; Neuronal helix-loop-helix transcription factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    31337465..31340726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    31475149..31478410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)