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Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 [ Mus musculus (house mouse) ]

Gene ID: 63959, updated on 1-Jan-2023

Summary

Official Symbol
Slc29a1provided by MGI
Official Full Name
solute carrier family 29 (nucleoside transporters), member 1provided by MGI
Primary source
MGI:MGI:1927073
See related
Ensembl:ENSMUSG00000023942 AllianceGenome:MGI:1927073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ENT1; 1200014D21Rik
Summary
Enables AMP transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and purine nucleoside transmembrane transporter activity. Involved in adenosine transport; neurotransmitter uptake; and purine nucleoside transmembrane transport. Acts upstream of or within nucleoside transport. Located in plasma membrane. Is expressed in several structures, including central nervous system; hemolymphoid system; hindlimb phalanx; liver; and skeletal musculature. Used to study alcohol dependence and diffuse idiopathic skeletal hyperostosis. Orthologous to human SLC29A1 (solute carrier family 29 member 1 (Augustine blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 135.7), adrenal adult (RPKM 95.4) and 26 other tissues See more
Orthologs
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Genomic context

See Slc29a1 in Genome Data Viewer
Location:
17; 17 B3- C
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45896126..45910544, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45585200..45599618, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 Neighboring gene predicted gene, 35399 Neighboring gene myomixer, myoblast fusion factor Neighboring gene predicted gene, 52283 Neighboring gene predicted gene, 25008

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in adenosine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenosine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleoside transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleoside transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleoside transport ISO
Inferred from Sequence Orthology
more info
 
involved_in purine nucleoside transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in purine nucleoside transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in pyrimidine-containing compound transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in uridine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in uridine transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
equilibrative nucleoside transporter 1
Names
NBMPR-sensitive equilibrative nucleoside transporter
equilibrative NBMPR-sensitive nucleoside transporter
equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter
nucleoside transporter, es-type
solute carrier family 29 member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199113.2NP_001186042.1  equilibrative nucleoside transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_001186042.1

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Consensus CDS
    CCDS57096.1
    UniProtKB/Swiss-Prot
    Q9JHF0, Q9JIM1
    UniProtKB/TrEMBL
    Q3TCZ2
    Related
    ENSMUSP00000131976.2, ENSMUST00000167692.8
    Conserved Domains (1) summary
    TIGR00939
    Location:18460
    2a57; Equilibrative Nucleoside Transporter (ENT)
  2. NM_001199114.2NP_001186043.1  equilibrative nucleoside transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_001186043.1

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Consensus CDS
    CCDS57096.1
    UniProtKB/Swiss-Prot
    Q9JHF0, Q9JIM1
    UniProtKB/TrEMBL
    Q3TCZ2
    Related
    ENSMUSP00000094923.4, ENSMUST00000097317.10
    Conserved Domains (1) summary
    TIGR00939
    Location:18460
    2a57; Equilibrative Nucleoside Transporter (ENT)
  3. NM_001199115.2NP_001186044.1  equilibrative nucleoside transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_001186044.1

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Consensus CDS
    CCDS28813.1
    UniProtKB/Swiss-Prot
    Q9JIM1
    UniProtKB/TrEMBL
    Q3TCZ2
    Related
    ENSMUSP00000126703.2, ENSMUST00000171847.8
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)
  4. NM_001199116.2NP_001186045.1  equilibrative nucleoside transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_001186045.1

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Consensus CDS
    CCDS28813.1
    UniProtKB/Swiss-Prot
    Q9JIM1
    UniProtKB/TrEMBL
    Q3TCZ2
    Related
    ENSMUSP00000063757.7, ENSMUST00000064889.13
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)
  5. NM_001357771.2NP_001344700.1  equilibrative nucleoside transporter 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Consensus CDS
    CCDS28813.1
    UniProtKB/TrEMBL
    Q3TCZ2
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)
  6. NM_001376987.1NP_001363916.1  equilibrative nucleoside transporter 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163677
    UniProtKB/Swiss-Prot
    Q9JHF0
    Conserved Domains (1) summary
    TIGR00939
    Location:18460
    2a57; Equilibrative Nucleoside Transporter (ENT)
  7. NM_001376988.1NP_001363917.1  equilibrative nucleoside transporter 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163677
    UniProtKB/Swiss-Prot
    Q9JHF0
    Related
    ENSMUSP00000063096.7, ENSMUST00000051574.13
    Conserved Domains (1) summary
    TIGR00939
    Location:18460
    2a57; Equilibrative Nucleoside Transporter (ENT)
  8. NM_001376989.1NP_001363918.1  equilibrative nucleoside transporter 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163677
    UniProtKB/Swiss-Prot
    Q9JHF0
    Conserved Domains (1) summary
    TIGR00939
    Location:18460
    2a57; Equilibrative Nucleoside Transporter (ENT)
  9. NM_001376990.1NP_001363919.1  equilibrative nucleoside transporter 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163677
    UniProtKB/Swiss-Prot
    Q9JHF0
    Conserved Domains (1) summary
    TIGR00939
    Location:18460
    2a57; Equilibrative Nucleoside Transporter (ENT)
  10. NM_001376991.1NP_001363920.1  equilibrative nucleoside transporter 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163677
    UniProtKB/TrEMBL
    Q3TCZ2
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)
  11. NM_001376992.1NP_001363921.1  equilibrative nucleoside transporter 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163677
    UniProtKB/TrEMBL
    Q3TCZ2
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)
  12. NM_001376993.1NP_001363922.1  equilibrative nucleoside transporter 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163677
    UniProtKB/TrEMBL
    Q3TCZ2
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)
  13. NM_001376994.1NP_001363923.1  equilibrative nucleoside transporter 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163677
    UniProtKB/TrEMBL
    Q3TCZ2
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)
  14. NM_001376995.1NP_001363924.1  equilibrative nucleoside transporter 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163677
    UniProtKB/TrEMBL
    Q3TCZ2
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)
  15. NM_001376996.1NP_001363925.1  equilibrative nucleoside transporter 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163677
    UniProtKB/TrEMBL
    Q3TCZ2
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)
  16. NM_001376997.1NP_001363926.1  equilibrative nucleoside transporter 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Conserved Domains (1) summary
    TIGR00939
    Location:1426
    2a57; Equilibrative Nucleoside Transporter (ENT)
  17. NM_001376998.1NP_001363927.1  equilibrative nucleoside transporter 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Conserved Domains (1) summary
    TIGR00939
    Location:1426
    2a57; Equilibrative Nucleoside Transporter (ENT)
  18. NM_022880.4NP_075018.1  equilibrative nucleoside transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_075018.1

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Consensus CDS
    CCDS28813.1
    UniProtKB/Swiss-Prot
    Q9JIM1
    UniProtKB/TrEMBL
    Q3TCZ2
    Related
    ENSMUSP00000129242.2, ENSMUST00000163492.8
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    45896126..45910544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160736.1XP_036016629.1  equilibrative nucleoside transporter 1 isoform X4

    Conserved Domains (1) summary
    TIGR00939
    Location:1426
    2a57; Equilibrative Nucleoside Transporter (ENT)
  2. XM_036160735.1XP_036016628.1  equilibrative nucleoside transporter 1 isoform X3

    Conserved Domains (1) summary
    TIGR00939
    Location:1428
    2a57; Equilibrative Nucleoside Transporter (ENT)
  3. XM_006524773.3XP_006524836.1  equilibrative nucleoside transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_006524836.1

    Conserved Domains (1) summary
    TIGR00939
    Location:1428
    2a57; Equilibrative Nucleoside Transporter (ENT)
  4. XM_036160734.1XP_036016627.1  equilibrative nucleoside transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9JHF0
    Conserved Domains (1) summary
    TIGR00939
    Location:18460
    2a57; Equilibrative Nucleoside Transporter (ENT)
  5. XM_030249966.2XP_030105826.1  equilibrative nucleoside transporter 1 isoform X2

    UniProtKB/TrEMBL
    Q3TCZ2
    Conserved Domains (1) summary
    TIGR00939
    Location:18458
    2a57; Equilibrative Nucleoside Transporter (ENT)