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Cables1 CDK5 and Abl enzyme substrate 1 [ Mus musculus (house mouse) ]

Gene ID: 63955, updated on 25-Dec-2022

Summary

Official Symbol
Cables1provided by MGI
Official Full Name
CDK5 and Abl enzyme substrate 1provided by MGI
Primary source
MGI:MGI:1927065
See related
Ensembl:ENSMUSG00000040957 AllianceGenome:MGI:1927065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ik3-1; Cables
Summary
Acts upstream of or within nervous system development. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and vibrissa. Orthologous to human CABLES1 (Cdk5 and Abl enzyme substrate 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 61.9), colon adult (RPKM 22.8) and 13 other tissues See more
Orthologs
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Genomic context

See Cables1 in Genome Data Viewer
Location:
18; 18 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (11972331..12078684)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (11839274..11945627)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene predicted gene, 41665 Neighboring gene predicted gene 6277 Neighboring gene microRNA 1901 Neighboring gene predicted gene, 41666 Neighboring gene transmembrane protein 241

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CDK5 and ABL1 enzyme substrate 1
Names
cdk3-binding protein ik3-1
interactor with CDK3 1
interactor-1 with cdk3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146287.2NP_001139759.1  CDK5 and ABL1 enzyme substrate 1 isoform 1

    See identical proteins and their annotated locations for NP_001139759.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC100751, AC132941
    Consensus CDS
    CCDS50220.1
    UniProtKB/TrEMBL
    Q3TYS6, Q3U148
    Related
    ENSMUSP00000129463.2, ENSMUST00000171109.9
    Conserved Domains (1) summary
    cd00043
    Location:477562
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  2. NM_022021.3NP_071304.2  CDK5 and ABL1 enzyme substrate 1 isoform 2

    See identical proteins and their annotated locations for NP_071304.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC100751, AC132941
    Consensus CDS
    CCDS29061.1
    UniProtKB/Swiss-Prot
    Q9EPR8, Q9ESJ1
    Related
    ENSMUSP00000040639.8, ENSMUST00000046948.10
    Conserved Domains (1) summary
    cd20602
    Location:437568
    CYCLIN_CABLES1; cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    11972331..12078684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)