Format

Send to:

Choose Destination

DMRTC2 DMRT like family C2 [ Homo sapiens (human) ]

Gene ID: 63946, updated on 18-Aug-2020

Summary

Official Symbol
DMRTC2provided by HGNC
Official Full Name
DMRT like family C2provided by HGNC
Primary source
HGNC:HGNC:13911
See related
Ensembl:ENSG00000142025 MIM:614806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 14.6) See more
Orthologs

Genomic context

See DMRTC2 in Genome Data Viewer
Location:
19q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41844743..41852333)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42348806..42356398)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 3 Neighboring gene CEA cell adhesion molecule 1 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 52 Neighboring gene LY6/PLAUR domain containing 4 Neighboring gene ribosomal protein S19 Neighboring gene microRNA 6797 Neighboring gene CD79a molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
male meiosis I IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone H3-K9 dimethylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone H3-K9 trimethylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
sex differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sex differentiation IEA
Inferred from Electronic Annotation
more info
 
spermatid nucleus elongation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
XY body IEA
Inferred from Electronic Annotation
more info
 
cellular_component ND
No biological Data available
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
doublesex- and mab-3-related transcription factor C2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040283.3NP_001035373.1  doublesex- and mab-3-related transcription factor C2

    See identical proteins and their annotated locations for NP_001035373.1

    Status: VALIDATED

    Source sequence(s)
    AC010616, AC243967, AJ291669, DB026313
    Consensus CDS
    CCDS33034.1
    UniProtKB/Swiss-Prot
    Q8IXT2
    Related
    ENSP00000269945.2, ENST00000269945.8
    Conserved Domains (2) summary
    pfam00751
    Location:3884
    DM; DM DNA binding domain
    pfam15791
    Location:240365
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41844743..41852333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027128.1XP_016882617.1  doublesex- and mab-3-related transcription factor C2 isoform X3

    UniProtKB/TrEMBL
    B4DX56
    Conserved Domains (2) summary
    pfam00751
    Location:3884
    DM; DM DNA binding domain
    pfam15791
    Location:240416
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
  2. XM_011527215.1XP_011525517.1  doublesex- and mab-3-related transcription factor C2 isoform X5

    See identical proteins and their annotated locations for XP_011525517.1

    Conserved Domains (1) summary
    pfam15791
    Location:117242
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
  3. XM_017027125.1XP_016882614.1  doublesex- and mab-3-related transcription factor C2 isoform X3

    UniProtKB/TrEMBL
    B4DX56
    Related
    ENSP00000469525.1, ENST00000596827.5
    Conserved Domains (2) summary
    pfam00751
    Location:3884
    DM; DM DNA binding domain
    pfam15791
    Location:240416
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
  4. XM_017027127.2XP_016882616.1  doublesex- and mab-3-related transcription factor C2 isoform X3

    UniProtKB/TrEMBL
    B4DX56
    Conserved Domains (2) summary
    pfam00751
    Location:3884
    DM; DM DNA binding domain
    pfam15791
    Location:240416
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
  5. XM_011527214.1XP_011525516.1  doublesex- and mab-3-related transcription factor C2 isoform X5

    See identical proteins and their annotated locations for XP_011525516.1

    Conserved Domains (1) summary
    pfam15791
    Location:117242
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
  6. XM_017027126.2XP_016882615.1  doublesex- and mab-3-related transcription factor C2 isoform X3

    UniProtKB/TrEMBL
    B4DX56
    Conserved Domains (2) summary
    pfam00751
    Location:3884
    DM; DM DNA binding domain
    pfam15791
    Location:240416
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
  7. XM_011527216.2XP_011525518.1  doublesex- and mab-3-related transcription factor C2 isoform X6

    Related
    ENSP00000472159.1, ENST00000601660.5
    Conserved Domains (1) summary
    pfam00751
    Location:4389
    DM; DM DNA binding domain
  8. XM_017027123.1XP_016882612.1  doublesex- and mab-3-related transcription factor C2 isoform X1

  9. XM_017027129.1XP_016882618.1  doublesex- and mab-3-related transcription factor C2 isoform X4

  10. XM_017027124.2XP_016882613.1  doublesex- and mab-3-related transcription factor C2 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033052.1: Suppressed sequence

    Description
    NM_033052.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center