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FKBPL FKBP prolyl isomerase like [ Homo sapiens (human) ]

Gene ID: 63943, updated on 13-Mar-2020

Summary

Official Symbol
FKBPLprovided by HGNC
Official Full Name
FKBP prolyl isomerase likeprovided by HGNC
Primary source
HGNC:HGNC:13949
See related
Ensembl:ENSG00000204315 MIM:617076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NG7; DIR1; FKBP4; WISP39
Summary
The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 3.5), thyroid (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See FKBPL in Genome Data Viewer
Location:
6p21.32
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (32128707..32130288, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (32096484..32098067, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tenascin XB Neighboring gene RNA, 5S ribosomal pseudogene 206 Neighboring gene activating transcription factor 6 beta Neighboring gene CRISPRi-validated cis-regulatory element chr6.1802 Neighboring gene uncharacterized LOC100507547 Neighboring gene proline rich transmembrane protein 1 Neighboring gene palmitoyl-protein thioesterase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein stabilization TAS
Traceable Author Statement
more info
 
regulation of blood vessel branching IEA
Inferred from Electronic Annotation
more info
 
response to radiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
FK506-binding protein-like
Names
FK506 binding protein like
WAF-1/CIP1 stabilizing protein 39
peptidyl-prolyl cis-trans isomerase
NP_071393.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022110.4NP_071393.2  FK506-binding protein-like

    See identical proteins and their annotated locations for NP_071393.2

    Status: REVIEWED

    Source sequence(s)
    AL662884
    Consensus CDS
    CCDS4738.1
    UniProtKB/Swiss-Prot
    Q9UIM3
    UniProtKB/TrEMBL
    A0A024RCQ6
    Related
    ENSP00000364298.3, ENST00000375156.4
    Conserved Domains (2) summary
    sd00006
    Location:210238
    TPR; TPR repeat [structural motif]
    cl26002
    Location:187348
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    32128707..32130288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    3567038..3568619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    3370071..3371652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    3470727..3472308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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