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PCIF1 phosphorylated CTD interacting factor 1 [ Homo sapiens (human) ]

Gene ID: 63935, updated on 4-Dec-2022

Summary

Official Symbol
PCIF1provided by HGNC
Official Full Name
phosphorylated CTD interacting factor 1provided by HGNC
Primary source
HGNC:HGNC:16200
See related
Ensembl:ENSG00000100982 MIM:618626; AllianceGenome:HGNC:16200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPAM; hCAPAM; hPCIF1; C20orf67; PPP1R121
Summary
Enables RNA polymerase II C-terminal domain phosphoserine binding activity; S-adenosyl-L-methionine binding activity; and mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA methylation; negative regulation of translation; and positive regulation of translation. Located in intercellular bridge; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 21.7), thyroid (RPKM 17.5) and 25 other tissues See more
Orthologs
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Genomic context

See PCIF1 in Genome Data Viewer
Location:
20q13.12
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45934683..45948020)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47670740..47684073)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44563322..44576659)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein Neighboring gene Sharpr-MPRA regulatory region 10402 Neighboring gene pre-mRNA-splicing factor cwc22-like Neighboring gene zinc finger protein 335 Neighboring gene ferritin light chain pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
Names
PDX-1 C terminus-interacting factor 1
PDX1 C-terminal inhibiting factor 1
cap-specific adenosine methyltransferase
protein phosphatase 1, regulatory subunit 121
NP_071387.1
XP_011527282.1
XP_011527283.1
XP_016883502.1
XP_047296324.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022104.4NP_071387.1  mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase

    See identical proteins and their annotated locations for NP_071387.1

    Status: VALIDATED

    Source sequence(s)
    BC013365, BQ684226
    Consensus CDS
    CCDS13388.1
    UniProtKB/Swiss-Prot
    Q9H4Z3, Q9NT85
    Related
    ENSP00000361486.3, ENST00000372409.8
    Conserved Domains (2) summary
    cd00201
    Location:4777
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam12237
    Location:446616
    PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    45934683..45948020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528980.4XP_011527282.1  mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011527282.1

    UniProtKB/Swiss-Prot
    Q9H4Z3, Q9NT85
    Conserved Domains (2) summary
    cd00201
    Location:4777
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam12237
    Location:446616
    PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain
  2. XM_017028013.3XP_016883502.1  mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q9H4Z3, Q9NT85
    Conserved Domains (2) summary
    cd00201
    Location:4777
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam12237
    Location:446616
    PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain
  3. XM_011528981.4XP_011527283.1  mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011527283.1

    UniProtKB/Swiss-Prot
    Q9H4Z3, Q9NT85
    Conserved Domains (2) summary
    cd00201
    Location:4777
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam12237
    Location:446616
    PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain
  4. XM_047440368.1XP_047296324.1  mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X2

RNA

  1. XR_936605.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    47670740..47684073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)