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PCIF1 PDX1 C-terminal inhibiting factor 1 [ Homo sapiens (human) ]

Gene ID: 63935, updated on 10-Oct-2019

Summary

Official Symbol
PCIF1provided by HGNC
Official Full Name
PDX1 C-terminal inhibiting factor 1provided by HGNC
Primary source
HGNC:HGNC:16200
See related
Ensembl:ENSG00000100982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPAM; hCAPAM; hPCIF1; C20orf67; PPP1R121
Expression
Ubiquitous expression in ovary (RPKM 21.7), thyroid (RPKM 17.5) and 25 other tissues See more
Orthologs

Genomic context

See PCIF1 in Genome Data Viewer
Location:
20q13.12
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (45934674..45948023)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44563313..44576732)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 25 Neighboring gene neuralized E3 ubiquitin protein ligase 2 Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein Neighboring gene pre-mRNA-splicing factor cwc22-like Neighboring gene zinc finger protein 335 Neighboring gene ferritin light chain pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
intercellular bridge IDA
Inferred from Direct Assay
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
Names
PDX-1 C terminus-interacting factor 1
cap-specific adenosine methyltransferase
phosphorylated CTD-interacting factor 1
protein phosphatase 1, regulatory subunit 121
NP_071387.1
XP_011527282.1
XP_011527283.1
XP_016883502.1
XP_016883503.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022104.4NP_071387.1  mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase

    See identical proteins and their annotated locations for NP_071387.1

    Status: VALIDATED

    Source sequence(s)
    BC013365, BQ684226
    Consensus CDS
    CCDS13388.1
    UniProtKB/Swiss-Prot
    Q9H4Z3
    Related
    ENSP00000361486.3, ENST00000372409.8
    Conserved Domains (2) summary
    cd00201
    Location:4777
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam12237
    Location:453616
    PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    45934674..45948023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028014.2XP_016883503.1  mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X2

    Conserved Domains (2) summary
    pfam12237
    Location:105268
    PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain
    pfam15547
    Location:1985
    DUF4654; Domain of unknown function (DUF4654)
  2. XM_011528980.3XP_011527282.1  mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011527282.1

    UniProtKB/Swiss-Prot
    Q9H4Z3
    Conserved Domains (2) summary
    cd00201
    Location:4777
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam12237
    Location:453616
    PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain
  3. XM_017028013.2XP_016883502.1  mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q9H4Z3
    Conserved Domains (2) summary
    cd00201
    Location:4777
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam12237
    Location:453616
    PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain
  4. XM_011528981.3XP_011527283.1  mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011527283.1

    UniProtKB/Swiss-Prot
    Q9H4Z3
    Conserved Domains (2) summary
    cd00201
    Location:4777
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam12237
    Location:453616
    PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain

RNA

  1. XR_936605.2 RNA Sequence

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