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ZNF335 zinc finger protein 335 [ Homo sapiens (human) ]

Gene ID: 63925, updated on 11-Jun-2021

Summary

Official Symbol
ZNF335provided by HGNC
Official Full Name
zinc finger protein 335provided by HGNC
Primary source
HGNC:HGNC:15807
See related
Ensembl:ENSG00000198026 MIM:610827
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIF1; NIF2; NIF-1; MCPH10
Summary
The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 8.9), skin (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF335 in Genome Data Viewer
Location:
20q13.12
Exon count:
27
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (45948653..45972910, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44577299..44600842, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein Neighboring gene pre-mRNA-splicing factor cwc22-like Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene ferritin light chain pseudogene 1 Neighboring gene SLC12A5 and MMP9 antisense RNA 1 Neighboring gene matrix metallopeptidase 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebral cortex neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3-K4 trimethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H3-K4 trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of histone H3-K4 methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger protein 335
Names
NRC-interacting factor 1
zinc-finger/leucine-zipper co-transducer NIF1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029772.1 RefSeqGene

    Range
    4992..28535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022095.4NP_071378.1  zinc finger protein 335

    See identical proteins and their annotated locations for NP_071378.1

    Status: REVIEWED

    Source sequence(s)
    AF395833, AL162458, BC041331, BF755826
    Consensus CDS
    CCDS13389.1
    UniProtKB/Swiss-Prot
    Q9H4Z2
    UniProtKB/TrEMBL
    Q8IW09
    Related
    ENSP00000325326.2, ENST00000322927.3
    Conserved Domains (6) summary
    PRK04654
    Location:795911
    PRK04654; sec-independent translocase; Provisional
    sd00017
    Location:10491069
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:529545
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:590612
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:10891114
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:10751097
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    45948653..45972910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260504.4XP_005260561.1  zinc finger protein 335 isoform X1

    Conserved Domains (6) summary
    PRK04654
    Location:794910
    PRK04654; sec-independent translocase; Provisional
    sd00017
    Location:10481068
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:528544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:589611
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:10881113
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:10741096
    zf-H2C2_5; C2H2-type zinc-finger domain
  2. XM_017028012.1XP_016883501.1  zinc finger protein 335 isoform X2

    Conserved Domains (5) summary
    PRK04654
    Location:619735
    PRK04654; sec-independent translocase; Provisional
    sd00017
    Location:873893
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:414436
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:913938
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:899921
    zf-H2C2_5; C2H2-type zinc-finger domain
  3. XM_011528979.3XP_011527281.1  zinc finger protein 335 isoform X3

    Conserved Domains (4) summary
    sd00017
    Location:564584
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:529545
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:590612
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:577600
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_002958501.1 RNA Sequence

  2. XR_002958500.1 RNA Sequence

  3. XR_936602.3 RNA Sequence

  4. XR_001754372.2 RNA Sequence

  5. XR_936604.3 RNA Sequence

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