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TNN tenascin N [ Homo sapiens (human) ]

Gene ID: 63923, updated on 28-Jun-2021

Summary

Official Symbol
TNNprovided by HGNC
Official Full Name
tenascin Nprovided by HGNC
Primary source
HGNC:HGNC:22942
See related
Ensembl:ENSG00000120332 MIM:617472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNW; TN-W
Expression
Biased expression in fat (RPKM 11.1), thyroid (RPKM 1.5) and 2 other tissues See more
Orthologs
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Genomic context

See TNN in Genome Data Viewer
Location:
1q25.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (175067833..175148075)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (175036969..175117211)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S14 Neighboring gene ENTR1 pseudogene 2 Neighboring gene KIAA0040 Neighboring gene ribosomal protein S29 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendrite self-avoidance ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron migration ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in negative regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of osteoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in osteoblast development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in CA3 pyramidal cell dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in hippocampal mossy fiber expansion IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tenascin-N
Names
TN-N
tenascin-W

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022093.2NP_071376.1  tenascin-N precursor

    See identical proteins and their annotated locations for NP_071376.1

    Status: VALIDATED

    Source sequence(s)
    AK127044, AL049689, Z99297, Z99715
    Consensus CDS
    CCDS30943.1
    UniProtKB/Swiss-Prot
    Q9UQP3
    UniProtKB/TrEMBL
    B3KXB6
    Related
    ENSP00000239462.4, ENST00000239462.9
    Conserved Domains (5) summary
    smart00060
    Location:798874
    FN3; Fibronectin type 3 domain
    cd00063
    Location:709791
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00087
    Location:10651276
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam00041
    Location:265342
    fn3; Fibronectin type III domain
    pfam07974
    Location:233259
    EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    175067833..175148075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002049.1XP_016857538.1  tenascin-N isoform X2

  2. XM_017002048.1XP_016857537.1  tenascin-N isoform X1

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