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CHTF18 chromosome transmission fidelity factor 18 [ Homo sapiens (human) ]

Gene ID: 63922, updated on 1-Jun-2020

Summary

Official Symbol
CHTF18provided by HGNC
Official Full Name
chromosome transmission fidelity factor 18provided by HGNC
Primary source
HGNC:HGNC:18435
See related
Ensembl:ENSG00000127586 MIM:613201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHL12; Ctf18; RUVBL; C16orf41; C321D2.2; C321D2.3; C321D2.4
Summary
This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016]
Expression
Broad expression in bone marrow (RPKM 7.1), testis (RPKM 6.3) and 24 other tissues See more
Orthologs

Genomic context

See CHTF18 in Genome Data Viewer
Location:
16p13.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (788620..798074)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (838622..848074)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene microRNA 662 Neighboring gene mesothelin like Neighboring gene RNA pseudouridine synthase domain containing 1 Neighboring gene G protein subunit gamma 13 Neighboring gene proline rich 25 Neighboring gene lipase maturation factor 1 Neighboring gene uncharacterized LOC107984876

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to DNA clamp loader activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to single-stranded DNA-dependent ATP-dependent DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA-dependent ATP-dependent DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Ctf18 RFC-like complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
chromosome transmission fidelity protein 18 homolog
Names
C321D2.3 (novel protein)
C321D2.4 (novel protein)
CTF18, chromosome transmission fidelity factor 18 homolog
homolog of yeast CHL12
some homology with holliday junction DNA helicase RUVB like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022092.3NP_071375.1  chromosome transmission fidelity protein 18 homolog

    See identical proteins and their annotated locations for NP_071375.1

    Status: VALIDATED

    Source sequence(s)
    AL031033
    Consensus CDS
    CCDS45371.1
    UniProtKB/Swiss-Prot
    Q8WVB6
    Related
    ENSP00000262315.9, ENST00000262315.14
    Conserved Domains (2) summary
    cd00009
    Location:352522
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cl19912
    Location:497559
    DNA_pol3_delta; DNA polymerase III, delta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    788620..798074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255471.3XP_005255528.1  chromosome transmission fidelity protein 18 homolog isoform X5

    See identical proteins and their annotated locations for XP_005255528.1

    UniProtKB/Swiss-Prot
    Q8WVB6
    Related
    ENSP00000406252.2, ENST00000455171.6
    Conserved Domains (2) summary
    cd00009
    Location:380550
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cl19912
    Location:525587
    DNA_pol3_delta; DNA polymerase III, delta subunit
  2. XM_017023534.1XP_016879023.1  chromosome transmission fidelity protein 18 homolog isoform X4

    Conserved Domains (2) summary
    cd00009
    Location:236406
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cl19912
    Location:381443
    DNA_pol3_delta; DNA polymerase III, delta subunit
  3. XM_005255470.1XP_005255527.1  chromosome transmission fidelity protein 18 homolog isoform X4

    Conserved Domains (2) summary
    cd00009
    Location:236406
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cl19912
    Location:381443
    DNA_pol3_delta; DNA polymerase III, delta subunit
  4. XM_011522572.1XP_011520874.1  chromosome transmission fidelity protein 18 homolog isoform X1

    Conserved Domains (2) summary
    cd00009
    Location:353523
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cl19912
    Location:498560
    DNA_pol3_delta; DNA polymerase III, delta subunit
  5. XM_017023533.1XP_016879022.1  chromosome transmission fidelity protein 18 homolog isoform X3

  6. XM_017023532.1XP_016879021.1  chromosome transmission fidelity protein 18 homolog isoform X2

  7. XM_011522573.1XP_011520875.1  chromosome transmission fidelity protein 18 homolog isoform X6

    See identical proteins and their annotated locations for XP_011520875.1

    UniProtKB/Swiss-Prot
    Q8WVB6
    Conserved Domains (1) summary
    cl19912
    Location:79141
    DNA_pol3_delta; DNA polymerase III, delta subunit
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