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GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 [ Homo sapiens (human) ]

Gene ID: 63917, updated on 13-Mar-2020

Summary

Official Symbol
GALNT11provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 11provided by HGNC
Primary source
HGNC:HGNC:19875
See related
Ensembl:ENSG00000178234 MIM:615130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GALNACT11; GALNAC-T11
Expression
Broad expression in kidney (RPKM 69.9), placenta (RPKM 22.3) and 24 other tissues See more
Orthologs

Genomic context

See GALNT11 in Genome Data Viewer
Location:
7q36.1; 7q36.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (152025674..152122345)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151722774..151819427)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375571 Neighboring gene polypeptide N-acetylgalactosaminyltransferase like 5 Neighboring gene uncharacterized LOC731075 Neighboring gene Y-box binding protein 1 pseudogene 4 Neighboring gene lysine methyltransferase 2C Neighboring gene septin 7 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21634, MGC71630

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch binding IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Notch receptor processing ISS
Inferred from Sequence or Structural Similarity
more info
 
Notch signaling involved in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
O-glycan processing TAS
Traceable Author Statement
more info
 
cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
determination of left/right symmetry ISS
Inferred from Sequence or Structural Similarity
more info
 
protein O-linked glycosylation via threonine IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
polypeptide N-acetylgalactosaminyltransferase 11
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
polypeptide GalNAc transferase 11
pp-GaNTase 11
protein-UDP acetylgalactosaminyltransferase 11
NP_001291443.1
NP_001358387.1
NP_001358388.1
NP_001358389.1
NP_001358390.1
NP_001358391.1
NP_001358392.1
NP_001358393.1
NP_001358394.1
NP_001358395.1
NP_001358396.1
NP_001358397.1
NP_001358398.1
NP_001358399.1
NP_001358400.1
NP_001358401.1
NP_001358402.1
NP_001358403.1
NP_001358404.1
NP_071370.2
XP_006716146.1
XP_006716147.1
XP_016867988.1
XP_024302625.1
XP_024302627.1
XP_024302628.1
XP_024302629.1
XP_024302630.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304514.2NP_001291443.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 2

    See identical proteins and their annotated locations for NP_001291443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks part of the 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC006017
    UniProtKB/TrEMBL
    B7Z5G5
    Conserved Domains (4) summary
    cd02510
    Location:73371
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:406525
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:402523
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:73301
    Glyco_tranf_2_3; Glycosyltransferase like family 2
  2. NM_001371458.1NP_001358387.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 4-8, encodes isoform 1.
    Source sequence(s)
    AC006017
  3. NM_001371459.1NP_001358388.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 3, and 5-8, encodes isoform 1.
    Source sequence(s)
    AC006017
  4. NM_001371460.1NP_001358389.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 3, 4, and 6-8, encodes isoform 1.
    Source sequence(s)
    AC006017
  5. NM_001371461.1NP_001358390.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 3-5, 7, and 8, encodes isoform 1.
    Source sequence(s)
    AC006017
  6. NM_001371462.1NP_001358391.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 3-6, and 8, encodes isoform 1.
    Source sequence(s)
    AC006017
  7. NM_001371463.1NP_001358392.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1 and 3-7, encodes isoform 1.
    Source sequence(s)
    AC006017
  8. NM_001371464.1NP_001358393.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) encodes the longest isoform (3).
    Source sequence(s)
    AC006017
  9. NM_001371465.1NP_001358394.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 11 and 12, encodes isoform 4.
    Source sequence(s)
    AC006017
  10. NM_001371466.1NP_001358395.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 10 and 12, encodes isoform 4.
    Source sequence(s)
    AC006017
  11. NM_001371467.1NP_001358396.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 10 and 11, encodes isoform 4.
    Source sequence(s)
    AC006017
  12. NM_001371468.1NP_001358397.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 14 and 15, encodes isoform 5.
    Source sequence(s)
    AC006017
  13. NM_001371469.1NP_001358398.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 13 and 15, encodes isoform 5.
    Source sequence(s)
    AC006017
  14. NM_001371470.1NP_001358399.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 13 and 14, encodes isoform 5.
    Source sequence(s)
    AC006017
  15. NM_001371471.1NP_001358400.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform 6.
    Source sequence(s)
    AC006017
  16. NM_001371472.1NP_001358401.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform 6.
    Source sequence(s)
    AC006017
  17. NM_001371473.1NP_001358402.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variant 19, encodes isoform 7.
    Source sequence(s)
    AC006017
    Related
    ENSP00000397581.1, ENST00000419245.5
  18. NM_001371474.1NP_001358403.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variant 18, encodes isoform 7.
    Source sequence(s)
    AC006017, BC059377
    Related
    ENSP00000410093.1, ENST00000415421.5
  19. NM_001371475.1NP_001358404.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC006017
  20. NM_022087.4NP_071370.2  polypeptide N-acetylgalactosaminyltransferase 11 isoform 1

    See identical proteins and their annotated locations for NP_071370.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 3-8, encodes isoform 1.
    Source sequence(s)
    AC006017
    Consensus CDS
    CCDS5930.1
    UniProtKB/Swiss-Prot
    Q8NCW6
    UniProtKB/TrEMBL
    A0A090N7X6
    Related
    ENSP00000395122.2, ENST00000430044.7
    Conserved Domains (2) summary
    cd02510
    Location:154452
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:483604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RNA

  1. NR_163956.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006017
  2. NR_163957.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006017
  3. NR_163958.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006017
  4. NR_163959.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006017

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    152025674..152122345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012499.2XP_016867988.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X2

  2. XM_024446857.1XP_024302625.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X1

    Related
    ENSP00000416787.1, ENST00000434507.5
    Conserved Domains (2) summary
    cd02510
    Location:154452
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:483604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  3. XM_024446859.1XP_024302627.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:154452
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:483604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  4. XM_024446860.1XP_024302628.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:154452
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:483604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  5. XM_024446861.1XP_024302629.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:154452
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:483604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  6. XM_006716084.2XP_006716147.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X1

    See identical proteins and their annotated locations for XP_006716147.1

    UniProtKB/Swiss-Prot
    Q8NCW6
    UniProtKB/TrEMBL
    A0A090N7X6
    Conserved Domains (2) summary
    cd02510
    Location:154452
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:483604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  7. XM_024446862.1XP_024302630.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:154452
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:483604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  8. XM_006716083.2XP_006716146.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X1

    See identical proteins and their annotated locations for XP_006716146.1

    UniProtKB/Swiss-Prot
    Q8NCW6
    UniProtKB/TrEMBL
    A0A090N7X6
    Conserved Domains (2) summary
    cd02510
    Location:154452
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:483604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
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