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GPATCH3 G-patch domain containing 3 [ Homo sapiens (human) ]

Gene ID: 63906, updated on 5-Aug-2022

Summary

Official Symbol
GPATCH3provided by HGNC
Official Full Name
G-patch domain containing 3provided by HGNC
Primary source
HGNC:HGNC:25720
See related
Ensembl:ENSG00000198746 MIM:617486; AllianceGenome:HGNC:25720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPATC3
Summary
Predicted to enable nucleic acid binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and positive regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 7.1), testis (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

See GPATCH3 in Genome Data Viewer
Location:
1p36.11
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26890488..26900467, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26728551..26738530, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27216979..27226958, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene stratifin Neighboring gene GPN-loop GTPase 2 Neighboring gene nuclear distribution C, dynein complex regulator Neighboring gene nuclear receptor subfamily 0 group B member 2 Neighboring gene Sharpr-MPRA regulatory region 10310

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12455, DKFZp686E0221

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G patch domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022078.3NP_071361.2  G patch domain-containing protein 3

    See identical proteins and their annotated locations for NP_071361.2

    Status: VALIDATED

    Source sequence(s)
    AW137695, BC007767, DA513389
    Consensus CDS
    CCDS290.1
    UniProtKB/Swiss-Prot
    Q96I76, Q9H9Z3
    Related
    ENSP00000354645.5, ENST00000361720.10
    Conserved Domains (1) summary
    smart00443
    Location:409456
    G_patch; glycine rich nucleic binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26890488..26900467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427518.1XP_047283474.1  G patch domain-containing protein 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    26728551..26738530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)